Protein Alignment Pkc98E and PRKCD

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 307/719 - (42%)
• Similarity: 427/719 - (59%)
• Gaps: 86/719 - (11%)

  Fly    33 ADEQLIDPYVSIDVDES-HFDRATT---RPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDD 93
            |:::...|:.::.:.|: ..:|..|   :..|..|.|...|...:.....|.:.:...|..|..:
Human    38 AEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSE 102

  Fly    94 FVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE--LKNRTDKAKAEAVVEHTVAVNKEFKE 156
            ......: ..:..:......:.|::|:||.|:.:.::  |::          |:...::..|.:.
Human   103 VTVGVSV-LAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLED----------VDCKQSMRSEDEA 156

  Fly   157 RAGFNRRRGAMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHL 220
            :.....||||::: ::|.:..|:|:|||..||||||.|::|:||:.||||:|:.|...:||||..
Human   157 KFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCID 221

  Fly   221 SVVSKCPG----MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQ 281
            .::.:|.|    .||....|       :|||:::||||.||:|...||||||||||:||:||||:
Human   222 KIIGRCTGTAANSRDTIFQK-------ERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLK 279

  Fly   282 CETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGAD 346
            ||.||||||.:|::.|||.||||.|.:||.|:.:    .::..|||
Human   280 CEDCGMNVHHKCREKVANLCGINQKLLAEALNQV----TQRASRRS------------------- 321

  Fly   347 GDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGG------VGATGETRPG--KC 403
                            ||.::....:..|:...       ||..|      .|..|:...|  ||
Human   322 ----------------DSASSEPVGIYQGFEKK-------TGVAGEDMQDNSGTYGKIWEGSSKC 363

  Fly   404 SLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPF 468
            ::.:|.|.|||||||||||:|.|.||..|.:|||.||||.::.||||:|||.|||:|.|||.:||
Human   364 NINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPF 428

  Fly   469 LTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDL 533
            ||.|...|||.|.||||||::||||||:.||...|||..||.|||||:...|||||:.|:|||||
Human   429 LTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDL 493

  Fly   534 KLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMY 598
            ||||:|||::||.|:||||||||.|......:||||||||||||||:..:|..|||||:.|||:|
Human   494 KLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLY 558

  Fly   599 EMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHP 663
            ||:.||.||..|:|||||:||..|...||.|:::|:..||:....:.|.:|||.||:   |:.||
Human   559 EMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGN---IKIHP 620

  Fly   664 FFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFV 728
            ||..::|..||||.::||||||:|:|||.:|||.||..|...|:.....::..::|..|||||||
Human   621 FFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFV 685

  Fly   729 NPKF 732
            ||||
Human   686 NPKF 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	18/106 (17%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	28/62 (45%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	37/53 (70%)
		STKc_nPKC_epsilon	412..729	CDD:270743	185/316 (59%)
PRKCD	NP_001341605.1	C1_nPKC_theta-like_rpt1	171..231	CDD:410384	28/59 (47%)
		C1_nPKC_theta-like_rpt2	250..299	CDD:410387	34/48 (71%)
		STKc_nPKC_delta	372..687	CDD:173710	186/317 (59%)