DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and PRKCB

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_002729.2	Gene:	PRKCB / 5579	HGNCID:	9395	Length:	673	Species:	Homo sapiens

Alignment Length:	680	Identity:	314/680 - (46%)
Similarity:	404/680 - (59%)	Gaps:	134/680 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            |:||:|:: ||:|..|||.|.|.:||||||||.:||||.||||:|||||..||||:||..|...|
Human    22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291
            || .|:.||..:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|||||
Human    87 PG-ADKGPASDD--PRSK-------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHK 141

  Fly   292 RCQKNVANTCGI-NTKQMAEI----------------------------LS----SLGISPDKQQ 323
            ||..||.:.||. :|::...|                            ||    .|.:.||.:.
Human   142 RCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

  Fly   324 PRRSK------YLNQQGGE---------------------------DNYGASL------------ 343
            ..:.|      .||.:..|                           :::..||
Human   207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASV 271

  Fly   344 ----------------------GADGDGAPGQSFRSCALSVDSLA--TSTTTMTSGYNSSSCMSL 384
                                  |::.:....|.|....:|..:..  ..||...|.::::.
Human   272 DGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNG---- 332

  Fly   385 AVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDD 449
                          ...:..|.||||:.||||||||||||:|:|||||:||:|:||||.:|||||
Human   333 --------------NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD 383

  Fly   450 VDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAA 514
            |:|||.|||:|||....||||.|||||||.|||:||||||||||||:.||:..||:...|.||||
Human   384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448

  Fly   515 EVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEIL 579
            |:.:.|.||.:.|:|||||||||::||.|||.|:||||||||.|.:|:.|.|||||||||||||:
Human   449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513

  Fly   580 KEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTK 644
            ..|.||.||||||.|||:|||:|||.|||.::|||||.|||..:|.||..:|:|||:|.||.:||
Human   514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578

  Fly   645 NPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTP 708
            :|.:||||..: |.:|::|.||..:||::||::.|:||::||... |:|.|||..||:..|||||
Human   579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFTRHPPVLTP 642

  Fly   709 IGNEVVRCINQDEFAGFSFVNPKF-GPERK 737
            ...||:|.|:|.||.||||||.:| .||.|
Human   643 PDQEVIRNIDQSEFEGFSFVNSEFLKPEVK 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	34/50 (68%)
		C1_1	252..304	CDD:278556	34/52 (65%)
		STKc_nPKC_epsilon	412..729	CDD:270743	202/317 (64%)
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	37/57 (65%)
		C1_cPKC_rpt2	102..155	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	12/129 (9%)
		STKc_cPKC_beta	341..663	CDD:270767	206/322 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950