Protein Alignment Pkc98E and PRKCA

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_002728.2
• Gene: PRKCA / 5578
• HGNCID: 9393
• Length: 672
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 314/666 - (47%)
• Similarity: 404/666 - (60%)
• Gaps: 114/666 - (17%)

  Fly   161 NR--RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSV 222
            ||  |:||:|:: ||:|..|||:|.|.:||||||||.:||||.||||:|||||..||||:||..|
Human    18 NRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFV 82

  Fly   223 VSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGM 287
            ...||| .|:.|...:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|
Human    83 TFSCPG-ADKGPDTDD--PRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137

  Fly   288 NVHKRCQKNVANTCGINTKQ-------MAEILS--------------------------SLGISP 319
            ||||:|..||.:.||::..:       .||:..                          .|.:.|
Human   138 NVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIP 202

  Fly   320 DKQQPRRSK------YLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTS---- 374
            |.:...:.|      .||.|..|........:|.|.         .|||:......||...
Human   203 DPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDR---------RLSVEIWDWDRTTRNDFMGS 258

  Fly   375 -GYNSSSCMSLAVTG---------------------------------SGGVGATG-------ET 398
             .:..|..|.:..:|                                 ...:|..|       |.
Human   259 LSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSED 323

  Fly   399 RP------GKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEK 457
            |.      .:..|.||||:.|||||||||||||::|||:|:||||:||||.:||||||:|||.||
Human   324 RKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 388

  Fly   458 RILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQF 522
            |:|||....||||.|||||||.|||:||||||||||||:.||:..:|:..:|.|||||:::.|.|
Human   389 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 453

  Fly   523 LHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGAS 587
            ||..|:|||||||||::||.|||.|:||||||||.:|:|:.|.|||||||||||||:..|.||.|
Human   454 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS 518

  Fly   588 VDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC 652
            |||||.|||:|||:||||||:.::|||||.|||..:|.||..||:||||:.||.:||:|.:||||
Human   519 VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGC 583

  Fly   653 TGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRC 716
            ..: |.::|:|.||.::||::||.|.|:|||:||:.. :.|.|||..||:..|||||....|:..
Human   584 GPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRGQPVLTPPDQLVIAN 647

  Fly   717 INQDEFAGFSFVNPKF 732
            |:|.:|.|||:|||:|
Human   648 IDQSDFEGFSYVNPQF 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	39/58 (67%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	33/53 (62%)
		STKc_nPKC_epsilon	412..729	CDD:270743	200/317 (63%)
PRKCA	NP_002728.2	C1_cPKC_rpt1	35..92	CDD:410383	37/57 (65%)
		C1_cPKC_rpt2	102..155	CDD:410386	33/52 (63%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	20/138 (14%)
		STKc_cPKC_alpha	328..668	CDD:270766	209/337 (62%)