DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and PRKCA

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_002728.2	Gene:	PRKCA / 5578	HGNCID:	9393	Length:	672	Species:	Homo sapiens

Alignment Length:	666	Identity:	314/666 - (47%)
Similarity:	404/666 - (60%)	Gaps:	114/666 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NR--RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSV 222
            ||  |:||:|:: ||:|..|||:|.|.:||||||||.:||||.||||:|||||..||||:||..|
Human    18 NRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFV 82

  Fly   223 VSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGM 287
            ...||| .|:.|...:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|
Human    83 TFSCPG-ADKGPDTDD--PRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137

  Fly   288 NVHKRCQKNVANTCGINTKQ-------MAEILS--------------------------SLGISP 319
            ||||:|..||.:.||::..:       .||:..                          .|.:.|
Human   138 NVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIP 202

  Fly   320 DKQQPRRSK------YLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTS---- 374
            |.:...:.|      .||.|..|........:|.|.         .|||:......||...
Human   203 DPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDR---------RLSVEIWDWDRTTRNDFMGS 258

  Fly   375 -GYNSSSCMSLAVTG---------------------------------SGGVGATG-------ET 398
             .:..|..|.:..:|                                 ...:|..|       |.
Human   259 LSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSED 323

  Fly   399 RP------GKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEK 457
            |.      .:..|.||||:.|||||||||||||::|||:|:||||:||||.:||||||:|||.||
Human   324 RKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 388

  Fly   458 RILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQF 522
            |:|||....||||.|||||||.|||:||||||||||||:.||:..:|:..:|.|||||:::.|.|
Human   389 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 453

  Fly   523 LHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGAS 587
            ||..|:|||||||||::||.|||.|:||||||||.:|:|:.|.|||||||||||||:..|.||.|
Human   454 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS 518

  Fly   588 VDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC 652
            |||||.|||:|||:||||||:.::|||||.|||..:|.||..||:||||:.||.:||:|.:||||
Human   519 VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGC 583

  Fly   653 TGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRC 716
            ..: |.::|:|.||.::||::||.|.|:|||:||:.. :.|.|||..||:..|||||....|:..
Human   584 GPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCG-KGAENFDKFFTRGQPVLTPPDQLVIAN 647

  Fly   717 INQDEFAGFSFVNPKF 732
            |:|.:|.|||:|||:|
Human   648 IDQSDFEGFSYVNPQF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	34/50 (68%)
		C1_1	252..304	CDD:278556	33/51 (65%)
		STKc_nPKC_epsilon	412..729	CDD:270743	200/317 (63%)
PRKCA	NP_002728.2	C1_1	37..89	CDD:278556	36/52 (69%)
		C1_1	102..154	CDD:278556	33/51 (65%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	20/138 (14%)
		STKc_cPKC_alpha	328..668	CDD:270766	209/337 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950