Protein Alignment Pkc98E and PRKACG

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 120/297 - (40%)
• Similarity: 183/297 - (61%)
• Gaps: 6/297 - (2%)

  Fly   408 FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTAL 472
            |..::.||.||||:|||...:.|...||:|:|.|..:::...|:..:.|||||. |.:.|||..|
Human    44 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQ-AIDFPFLVKL 107

  Fly   473 HSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDN 537
            ...|:....|:.|||||.||::..::|:..||....|.||||:|.||:|:||:..:|:||||.:|
Human   108 QFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPEN 172

  Fly   538 ILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMA 602
            :|:||:|:.::.|||..|.  :.|. |.|.||||:|:||||:..:.|..:|||||||||:|||..
Human   173 LLIDQQGYLQVTDFGFAKR--VKGR-TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAV 234

  Fly   603 GQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLG-CTGDENEIRKHPFFA 666
            |.|||.||...::::.|:...|.:|..||.:...:|:..|..:..:|.| ......:|:.|.:||
Human   235 GFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFA 299

  Fly   667 KLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            ...|..:.::.::.||.||...|.||:||| ::.:|:
Human   300 TTSWIAIYEKKVEAPFIPKYTGPGDASNFD-DYEEEE 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388
		STKc_nPKC_epsilon	412..729	CDD:270743	119/293 (41%)
PRKACG	NP_002723.2	STKc_PKA	42..331	CDD:271111	119/291 (41%)