Protein Alignment Pkc98E and PRKACB

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_891993.1
• Gene: PRKACB / 5567
• HGNCID: 9381
• Length: 398
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 122/300 - (40%)
• Similarity: 185/300 - (61%)
• Gaps: 6/300 - (2%)

  Fly   405 LLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFL 469
            |.||...|.||.||||:|||.:.|.|::.||:|:|.|..:::...::.|:.|||||. |.|.|||
Human    88 LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVNFPFL 151

  Fly   470 TALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLK 534
            ..|...|:....|:.|||||.||::...:::..||....|.||||::.|..::||:..:||||||
Human   152 VRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 216

  Fly   535 LDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYE 599
            .:|:|:|.:|:.::.|||..|.  :.|. |.|.||||:|:||||:..:.|..:|||||||||:||
Human   217 PENLLIDHQGYIQVTDFGFAKR--VKGR-TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE 278

  Fly   600 MMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLG-CTGDENEIRKHP 663
            |.||.|||.||...::::.|:...|.:|...|.:...:|:..|..:..:|.| .....::|:.|.
Human   279 MAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHK 343

  Fly   664 FFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            :||..||..:.:|.::.||.||.:...|.:||| ::.:||
Human   344 WFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFD-DYEEED 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388
		STKc_nPKC_epsilon	412..729	CDD:270743	118/292 (40%)
PRKACB	NP_891993.1	STKc_PKA	89..378	CDD:271111	119/293 (41%)