DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and prkchb

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001038271.1	Gene:	prkchb / 556591	ZFINID:	ZDB-GENE-041001-104	Length:	676	Species:	Danio rerio

Alignment Length:	741	Identity:	371/741 - (50%)
Similarity:	482/741 - (65%)	Gaps:	82/741 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::.:.||..|:||.|..||  ||.:...   :|||:.:.||.....:..|:|||..|.:|
Zfish     3 FNGYLRLHIREAVDLKPTRFSTRH--TFNRKIQ---LDPYIVVKVDNVKHAKTATKPKTNKPTFN 62

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDL--WVNLEPQGKIHVII 129
            |:|...::|...:.|.|||...|..|.|||||.|..:::..:.......  ||||||:|.:::.|
Zfish    63 EEFCPYISNGVELELAVFHSTRLGYDTFVANCRIQLKEITTTPGTKPKFEGWVNLEPEGSVYIFI 127

  Fly   130 ELKNR-TDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            .|... ||.   |||  :.|..:|||.      |::...||:|||:.|||||||||.|||||.||
Zfish   128 TLTGSFTDD---EAV--NIVKTHKEFV------RKKVLKRRKVHQIYGHKFMATFLPQPTFCYHC 181

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQR--FNVNLPHRFV 255
            :.|||| ||||||||||||.||||:||..||::||.||.:       ...|||  |::||||:|.
Zfish   182 KNFIWGVIGKQGYQCQVCTCVVHKRCHALVVTECPRMRKD-------ANEGQRQGFSINLPHQFK 239

  Fly   256 VHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGI--S 318
            .|:||..|:|:|||||||||:||||.|:.|.||:||||::|||..||::..::|..||.:|:  :
Zfish   240 EHNYKVPTYCNHCGSLLYGLVKQGLHCKICKMNIHKRCEQNVAPNCGVDNAELASKLSEIGLLNT 304

  Fly   319 PDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMS 383
            ..|::.:.|.:::                             ||.|.:::|:..|:...|
Zfish   305 ISKRKSQGSLHMS-----------------------------SVRSQSSTTSIETTEEES----- 335

  Fly   384 LAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDD 448
                         :....|..|.||:|::|||||||||||||..|....::|:|:||||.|:|:|
Zfish   336 -------------DEEAVKVCLEDFSFLQVLGKGSFGKVMLARLKSDHRVFAVKMLKKDVILQED 387

  Fly   449 DVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYA 513
            ||:.||||||:|.||..|||||.|:.||||.:|||||||:||||||||.|||.|||:..||.|||
Zfish   388 DVEATMTEKRVLTLAHQHPFLTQLYYCFQTTERLFFVMEFVNGGDLMFHIQKCRRFDEPRAQFYA 452

  Fly   514 AEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEI 578
            ||||.||:|||:.|:|||||||||||||::|||||||||||||.|.||.||:|||||||||||||
Zfish   453 AEVTSALKFLHSKGIIYRDLKLDNILLDRDGHCKLADFGMCKEEIFNGKLTSTFCGTPDYIAPEI 517

  Fly   579 LKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLT 643
            |:|:.||.||||||||||:|||::|..||||:.|||||:.|:.|:::|..|||.||..||||.||
Zfish   518 LQEELYGVSVDWWALGVLLYEMLSGHAPFEAETEDELFECILKDEIIYSSWLSYEAEDILKGLLT 582

  Fly   644 KNPEQRLGC---TGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPV 705
            ::|..||||   .|.|..|..|.||..|||::|.:|.|.|||.|::.:..|.||||.:||:|||.
Zfish   583 RDPACRLGCIDNDGGEEAITAHAFFTGLDWEKLYRREITPPFTPRINSIEDVNNFDPDFTQEDPC 647

  Fly   706 LTPIGNEVVRCINQDEFAGFSFVNPK 731
            |||| .|.:...:||.|..||::.|:
Zfish   648 LTPI-EESLFPFHQDGFKDFSYIAPE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	48/133 (36%)
		C1_1	177..228	CDD:278556	40/51 (78%)
		C1_1	252..304	CDD:278556	33/51 (65%)
		STKc_nPKC_epsilon	412..729	CDD:270743	206/319 (65%)
prkchb	NP_001038271.1	C2_PKC_epsilon	3..133	CDD:175981	48/134 (36%)
		C1_1	165..216	CDD:278556	39/50 (78%)
		C1_1	236..288	CDD:278556	33/51 (65%)
		S_TKc	347..607	CDD:214567	176/259 (68%)
		PKc_like	351..673	CDD:304357	207/323 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7160
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.790