Protein Alignment Pkc98E and prkcz

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001025262.1
• Gene: prkcz / 555737
• ZFINID: ZDB-GENE-070511-1
• Length: 599
• Species: Danio rerio
• Alignment Length: 592
• Identity: 232/592 - (39%)
• Similarity: 313/592 - (52%)
• Gaps: 141/592 - (23%)

  Fly   163 RRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            ||||.| |::::||||.|.|....:..:|.||.|.|||:|:|||:|..|.|:|||:||..|...|
Zfish   116 RRGARRWRKLYRVNGHLFQAKRFNRKAYCGHCSERIWGLGRQGYKCINCKLLVHKRCHKLVPLTC 180

  Fly   227 -----PGMRDEQP--------AKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQ 278
                 |.|..::|        .:||:.|........:|..|:.|:.|
Zfish   181 QRHMDPVMPSQEPLVDDDKSGEEVELPPEDPEDTDAIPVPFLAHNRK------------------ 227

  Fly   279 GLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASL 343
                      |.|                                           .||: ...|
Zfish   228 ----------VEK-------------------------------------------AEDD-SEDL 238

  Fly   344 GADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDF 408
            .|..||..|.....|.                               |:|             ||
Zfish   239 KAVVDGIEGIQISQCL-------------------------------GLG-------------DF 259

  Fly   409 NFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALH 473
            :.|:|:|:||:.||:|...|..::|||:||:||:.:..|:|:|...|||.:...|:.:|||..||
Zfish   260 DLIRVIGRGSYAKVLLVRLKKNEQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASTNPFLVGLH 324

  Fly   474 SCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNI 538
            |||||..|||.|:||||||||||.:|:.|:.....|.|||||:.:||.|||..|:|||||||||:
Zfish   325 SCFQTESRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHEKGIIYRDLKLDNV 389

  Fly   539 LLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAG 603
            ||||:||.||.|:|||||||..|..|:||||||:|||||||:.::||.|||||||||||:|||||
Zfish   390 LLDQDGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAG 454

  Fly   604 QPPFE--ADN-----EDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC---TGDENE 658
            :.||:  .||     |:.||..|:...:..|..||.:|.|:|||||.|:|::||||   || ..:
Zfish   455 RSPFDIITDNPDMNTEEYLFQVILEKPIRIPRSLSVKAASVLKGFLNKDPKERLGCQVQTG-FTD 518

  Fly   659 IRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFA 723
            |:.|.||..:||.:||::.:.|||:|::.:.....|||.:||.|...|||...:|::.|:|.||.
Zfish   519 IKSHTFFRSIDWDQLEQKQVTPPFKPQITDDYGLENFDTQFTNEPVQLTPDDEDVIKRIDQSEFE 583

  Fly   724 GFSFVNP 730
            ||.::||
Zfish   584 GFEYINP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	28/63 (44%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	6/53 (11%)
		STKc_nPKC_epsilon	412..729	CDD:270743	172/326 (53%)
prkcz	NP_001025262.1	PB1	16..98	CDD:413452
		C1_aPKC_zeta	129..183	CDD:410448	26/53 (49%)
		STKc_aPKC_zeta	243..599	CDD:270768	183/393 (47%)