Protein Alignment Pkc98E and aPKC

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 642
• Identity: 238/642 - (37%)
• Similarity: 328/642 - (51%)
• Gaps: 158/642 - (24%)

  Fly   106 MQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMR-R 169
            :|||..::..:..:.|.                     |.....::.:.::|:.:  ||||.| |
  Fly   449 LQSEEEIEPAYATVFPN---------------------VPQAPGLSCDGEDRSIY--RRGARRWR 490

  Fly   170 RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC-----PGM 229
            ::::||||.|.|....:..||::|::.|||:|:||::|..|.|:||||||..|...|     |.:
  Fly   491 KLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLV 555

  Fly   230 RDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQ 294
            ::......:.:|      |.||                  .|.|..:..|  .|.|..:.|
  Fly   556 KERAEESSDPIP------VPLP------------------PLPYEAMSGG--AEACETHDH---- 590

  Fly   295 KNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCA 359
                          |.|::    .|..:.|.      :.|.:..|
  Fly   591 --------------AHIVA----PPPPEDPL------EPGTQRQY-------------------- 611

  Fly   360 LSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVML 424
                                                        ||.||..|:|:|:||:.||::
  Fly   612 --------------------------------------------SLNDFELIRVIGRGSYAKVLM 632

  Fly   425 AEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYV 489
            .|.:.|..|||:||:||..:..|:|:|...|||.:...|:|||||..||||||||.|||||:|:|
  Fly   633 VELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFV 697

  Fly   490 NGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMC 554
            .|||||:.:|:.||.....|.|||||::|||.|||..|:|||||||||:|||.|||.||.|:|||
  Fly   698 RGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMC 762

  Fly   555 KEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF---------EAD 610
            ||||..|..|:||||||:|||||||:.::||.||||||||||:|||:||:.||         :.:
  Fly   763 KEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQN 827

  Fly   611 NEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDE--NEIRKHPFFAKLDWKEL 673
            .||.||..|:...:..|..||..|.|:|||||.|||..||||..:.  .:|..||||..:||:.|
  Fly   828 TEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELL 892

  Fly   674 EKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            |::.:.|||:|::.:.||..||..|||.|...|||..:.|:..|:|.||.||.:|||
  Fly   893 ERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	4/27 (15%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	27/63 (43%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	8/53 (15%)
		STKc_nPKC_epsilon	412..729	CDD:270743	175/327 (54%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	25/53 (47%)
		STKc_aPKC	620..947	CDD:270740	175/326 (54%)