Protein Alignment Pkc98E and unc-13

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001245427.1
• Gene: unc-13 / 43841
• FlyBaseID: FBgn0025726
• Length: 3186
• Species: Drosophila melanogaster
• Alignment Length: 294
• Identity: 67/294 - (22%)
• Similarity: 104/294 - (35%)
• Gaps: 102/294 - (34%)

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            ::.|:.|.|..|.||...|             .....||||::.|.:.. .|..|.|:..:||||
  Fly  2158 WSAKIAITVICAQGLIAKD-------------KSGTSDPYVTVQVSKVK-KRTRTMPQELNPVWN 2208

  Fly    67 EQFVHDVTNVSN-INLTVFHD-----------AALPPDDFVANCIISFEDLMQSETAVQDLWVNL 119
            |:|..:..|.|: |.:.|:.:           .....|||:...||....|    :...|:|.||
  Fly  2209 EKFHFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTL----SGEMDVWYNL 2269

  Fly   120 EPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVH-QVNGHKFMATF 183
            |            .||||:          ||:             ||:|..:. ::.|.:.:|.:
  Fly  2270 E------------KRTDKS----------AVS-------------GAIRLHISVEIKGEEKVAPY 2299

  Fly   184 LRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMR---------DEQPAKVEM 239
            ..|.| |.|...|       .|.|:..|.:|          |.|..:         ||.|.:: :
  Fly  2300 HVQYT-CLHENLF-------HYLCEENTGMV----------KLPTQKGDDAWKLYFDEIPEEI-V 2345

  Fly   240 VPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLY 273
            .....|:.:...::.:.|.        ||.|..|
  Fly  2346 DEFSMRYGIENIYQAMTHF--------HCLSAKY 2371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	36/143 (25%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	13/59 (22%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	5/24 (21%)
		STKc_nPKC_epsilon	412..729	CDD:270743
unc-13	NP_001245427.1	C1	2019..2100	CDD:412127
		C2B_Munc13	2160..2286	CDD:175993	45/178 (25%)
		MUN	2477..2996	CDD:461870
		C2C_Munc13	3032..3152	CDD:176041