DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Akt1

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	308	Identity:	158/308 - (51%)
Similarity:	218/308 - (70%)	Gaps:	2/308 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 KCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANH 466
            |.:|.:|.|:||||||:||||:|..:|.|.::||||:|||:.|||.|:|..|:||.|:|. :.||
  Fly   260 KVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNH 323

  Fly   467 PFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYR 531
            |||.:|...|||.|||.|||:|||||:|.:.:...|.|...|..||.||:..||.:||:.|:|||
  Fly   324 PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYR 388

  Fly   532 DLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVL 596
            ||||:|:|||::||.|:||||:|||.|..|..|.||||||:|:|||:|.:.:||.:||||..||:
  Fly   389 DLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVV 453

  Fly   597 MYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDE-NEIR 660
            ||||:.|:.||...:.|.||..|:.::|.:|..::.||.::|.|.|.|:|::|||...|: .||:
  Fly   454 MYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQ 518

  Fly   661 KHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTP 708
            .|||||.::|.:|..:.|.|||:|::.:..|...||.|||.|...|||
  Fly   519 AHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTP 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	154/298 (52%)
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	136/257 (53%)
		STKc_PKB	270..590	CDD:270723	154/298 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.070