DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and dop

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	147/499 - (29%)
Similarity:	241/499 - (48%)	Gaps:	77/499 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 VANTCGINTKQMAEILSSL-----------GISPDKQQPRRSKYLNQ---QGGEDNYGASLGA-- 345
            :.:..|:|...:||:...|           .:..|...|..|..||.   ...:.....:|.|
  Fly   689 IIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIA 753

  Fly   346 ----DGDGAPGQ----------SFRSCALSVDSL----ATSTTTMTSGYNSSSCMSLAVTGSGGV 392
                .|...|.|          :..|.||::..:    ..|::.:..|.:|....:..:||....
  Fly   754 MDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAA 818

  Fly   393 GATG----ETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCT 453
            .|||    :..|.:   .||:.:|::..|::|.|.|.:.|.|.:.:|:|.:.|:.:|..:.|:..
  Fly   819 TATGSGAQQPSPQE---NDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQV 880

  Fly   454 MTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTL 518
            ..|:.||:.|.| ||:.:::..|:|...|..|||||.|||....::......|..|.||.||..|
  Fly   881 FAERDILSFADN-PFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVL 944

  Fly   519 ALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMN-------GML---TTTFC----- 568
            |:::||::|:::||||.||:|:...||.||.|||:.|.|:|:       |.:   |..|.
  Fly   945 AVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVY 1009

  Fly   569 GTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYP---VW- 629
            |||:|||||::..|.||..||||::|:::||.:.|..||..:..:|||...::||:.:|   .|
  Fly  1010 GTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWP 1074

  Fly   630 LSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANN 694
            :..||..|:...|.:||..|||......|:::|.:|..:||..|.::  |..|.|::.:..|.:.
  Fly  1075 VQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQ--KAEFVPQLSHDDDTSY 1137

  Fly   695 FDAEFTKEDPVLTPIGNEVVRCINQDE------FAGFSFVNPKF 732
            ||   |:.|.....:|.|     :.|:      |..|:...|::
  Fly  1138 FD---TRMDRYNHDLGGE-----DTDDTDDTPVFGSFNSYTPQY 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556	1/6 (17%)
		STKc_nPKC_epsilon	412..729	CDD:270743	117/341 (34%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	2/12 (17%)
		STKc_MAST	834..1115	CDD:270760	103/281 (37%)
		S_TKc	835..1110	CDD:214567	101/275 (37%)
		PDZ_signaling	1506..1587	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100