DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and akt2

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_937789.1	Gene:	akt2 / 378972	ZFINID:	ZDB-GENE-031007-5	Length:	479	Species:	Danio rerio

Alignment Length:	337	Identity:	156/337 - (46%)
Similarity:	224/337 - (66%)	Gaps:	16/337 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 GYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVL 439
            |.||...|..|:|.|          ..|.::.||:::|:||||:||||:|..:|.|...||:|:|
Zfish   127 GDNSLEGMEAAITKS----------RTKVTMSDFDYLKLLGKGTFGKVILVREKATGMYYAMKIL 181

  Fly   440 KKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRF 504
            :|:.||..|:|..|:||.|:|. ...|||||.|...|||.|||.|||||.|||:|.|.:.:.|.|
Zfish   182 RKEVIIAKDEVAHTITESRVLQ-NTRHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVF 245

  Fly   505 EASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCG 569
            ...||.||.||:..||::||:..|:||||||:|::||::||.|:.|||:|||||.|.....||||
Zfish   246 TEDRARFYGAEIVSALEYLHSKDVVYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFCG 310

  Fly   570 TPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREA 634
            ||:|:|||:|::.:||.:||||.|||:|||||.|:.||...:.:.||:.|:.:::.:|..||.||
Zfish   311 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRNLSPEA 375

  Fly   635 VSILKGFLTKNPEQRLGCTG---DENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFD 696
            .::|.|.|.|:|:||||  |   |..|:..|.||..::|:::.::.:.|||:|::.:..|...||
Zfish   376 KALLAGLLKKDPKQRLG--GGPEDAKEVMTHKFFNNMNWQDVLQKKLVPPFKPQVTSETDTRYFD 438

  Fly   697 AEFTKEDPVLTP 708
            .|||.:...:||
Zfish   439 DEFTAQTITVTP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	146/300 (49%)
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947
		PH	6..106	CDD:278594
		S_TKc	150..407	CDD:214567	132/259 (51%)
		STKc_PKB_beta	154..476	CDD:173686	146/300 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910