DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and inaC

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_476863.1	Gene:	inaC / 36897	FlyBaseID:	FBgn0004784	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	700	Identity:	267/700 - (38%)
Similarity:	367/700 - (52%)	Gaps:	129/700 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 LEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRR-VHQVNGHKFMAT 182
            ||..|:.:::..:|||.                           |:|||:|: :..||||:|...
  Fly    40 LEITGEANIVNYMKNRL---------------------------RKGAMKRKGLEMVNGHRFGVR 77

  Fly   183 FLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMR---DEQPAKVEMVPAGQ 244
            |.:.||:|.||::||||.||||:||:.|...:|:||...||.||||..   |...|||:
  Fly    78 FFKNPTYCGHCKDFIWGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVK------ 136

  Fly   245 RFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMA 309
                   |.::..:|...||||.||.||:|:..||::||.|.:|||..||:.|...||.:   ::
  Fly   137 -------HGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGAD---IS 191

  Fly   310 EILSSL---------GISPDKQQPRRSKYLNQQGGEDNY-GASLGADGDGAPGQSFRSCALSVDS 364
            |:...|         .:..|.::......::..|..|.| ...:..|..|...:..::...:::.
  Fly   192 EVRGKLLLYVELKGNNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNP 256

  Fly   365 LATST----------------------TTMTSGYNSSSCMSLAVTGSGGVG--------ATGE-- 397
            :...|                      .|..:.:..|...||.......|.        ..||
  Fly   257 VFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHY 321

  Fly   398 ---------------------TRPGK------------------CSLLDFNFIKVLGKGSFGKVM 423
                                 .||.:                  ....||||:||:||||||||:
  Fly   322 NIPCVDAFNDIARLRDEVRHDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVL 386

  Fly   424 LAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEY 488
            |||::||||:||:|||:||.|||.||::..|.||:||||:...|||.::||||||.|||||||||
  Fly   387 LAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEY 451

  Fly   489 VNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGM 553
            ..|||||:.:|:..||:.|.|.|||.||.:||.|||...:|||||||||||||.|||.||.|||:
  Fly   452 CKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGL 516

  Fly   554 CKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDS 618
            .|||:.....|.||||||:|:||||:....|..:.|||:.|||::|.||||.|||.|:|..:|.:
  Fly   517 SKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRN 581

  Fly   619 IMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAKLDWKELEKRNIKPPF 682
            |.....::|...|.||:.|:..||||.|..|||. .....||..||||..:||.:.|...::||.
  Fly   582 IKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPI 646

  Fly   683 RPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
            :|.:|:.:|.:|||..||||...|||.....:..::|::|.||||:||:|
  Fly   647 KPMIKHRKDISNFDDAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFMNPEF 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	4/14 (29%)
		C1_1	177..228	CDD:278556	26/50 (52%)
		C1_1	252..304	CDD:278556	24/51 (47%)
		STKc_nPKC_epsilon	412..729	CDD:270743	172/317 (54%)
inaC	NP_476863.1	C1_1	72..124	CDD:278556	27/51 (53%)
		C1_1	137..189	CDD:278556	24/51 (47%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	15/129 (12%)
		S_TKc	371..629	CDD:214567	149/257 (58%)
		STKc_PKC	375..692	CDD:270722	171/316 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452322
Domainoid	1	1.000	46	1.000	Domainoid score	I3535
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27201at7147
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000