DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and pkn3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_003198687.2	Gene:	pkn3 / 323182	ZFINID:	ZDB-GENE-030131-1902	Length:	940	Species:	Danio rerio

Alignment Length:	770	Identity:	238/770 - (30%)
Similarity:	345/770 - (44%)	Gaps:	195/770 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TGKLQIKV-------------CEASGL-----RPTD---FQKRHNL----TFGKLADEQLIDPYV 42
            ||:|::::             |..|.:     .|:|   .:.|..|    |.||......:...:
Zfish   317 TGRLEVRLMGCQDLLESVPGRCRVSNMSSAPGSPSDSKSLRMRTGLSTRSTNGKTTKTDELSSEI 381

  Fly    43 S--IDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF--- 102
            |  :.||.....|...||.:.| .||:.|..::.....:.:.|:.      .|:.:.|.:.|
Zfish   382 SAVLKVDNKIVGRTHWRPLSKD-AWNQSFSIELERSRELEIAVYW------RDWRSLCAVKFLRL 439

  Fly   103 EDLMQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAM 167
            ||.:.::.  ..:.:.|||||.:...:...|        .|:|....:.   :::..|.:.:|..
Zfish   440 EDFLDNQR--HGMCLYLEPQGTLFTEVRFIN--------PVIERHPKLQ---RQKRIFPKEKGKN 491

  Fly   168 RRRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC------ 226
            ..|..|:|.:  .||               ||                 :..:||:..|
Zfish   492 FLRAAQMNMN--FAT---------------WG-----------------RLMMSVLPPCNSTITA 522

  Fly   227 -----PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCG 286
                 ||.....|..|...|
Zfish   523 LSPPLPGSEPLSPPSVSTPP--------------------------------------------- 542

  Fly   287 MNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAP 351
                             :|...|.:  .|..|.::.......:|.|....|.   ||    .|.|
Zfish   543 -----------------STGDSAVV--KLNFSEERPTKPPRLHLAQNPSADE---SL----SGTP 581

  Fly   352 GQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGK 416
            .:        |:|  |....:.....:|.             .|.:.:.| ..:.|||.|.|||:
Zfish   582 AR--------VNS--TEDRRVLQARPASQ-------------PTPQRKEG-MQMEDFNCISVLGR 622

  Fly   417 GSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILAL--AANHPFLTALHSCFQTP 479
            |.||||:|||.|.|.::||||.|||..::..|:||..|.||||...  |:.||||..|:.|||||
Zfish   623 GHFGKVLLAEFKRTGKLYAIKALKKGDVVTRDEVDSLMCEKRIFETINASRHPFLVNLYGCFQTP 687

  Fly   480 DRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEG 544
            |.:.|||||..|||||..|.. ..|...:|.||:|.|.|.|:|||.:.::||||||||:|:|.:|
Zfish   688 DHVCFVMEYSPGGDLMTHIHN-NIFSERQARFYSACVLLGLEFLHQNRIVYRDLKLDNLLMDSDG 751

  Fly   545 HCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEA 609
            ..::||||:||||:..|..|:||||||:::|||:|.:..|..:||||.||||:|||:.|:.||..
Zfish   752 FVRIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDSNYTRAVDWWGLGVLIYEMLVGESPFPG 816

  Fly   610 DNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAKLDWKEL 673
            |:|:|:||||::|:|.||.::|.|:||:::..|.||.|:|||. ..|.||::||.||..:||:.|
Zfish   817 DDEEEVFDSIVNDEVRYPRFMSPESVSVIQKLLQKNSEKRLGAGEQDANEVKKHRFFQGIDWEAL 881

  Fly   674 EKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDE-FAGFSF 727
            ..:.:||||.|.:|...|.:|||.|||:..|||||..........|.| ||.|.|
Zfish   882 LAKRVKPPFLPSIKTAADVSNFDEEFTRLKPVLTPPQTPFFLSAEQQEFFADFDF 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	33/160 (21%)
		C1_1	177..228	CDD:278556	7/61 (11%)
		C1_1	252..304	CDD:278556	0/51 (0%)
		STKc_nPKC_epsilon	412..729	CDD:270743	164/320 (51%)
pkn3	XP_003198687.2	HR1_PKN_1	25..90	CDD:212012
		HR1	111..183	CDD:320753
		HR1_PKN3_3	199..271	CDD:212027
		C2_PKN-like	379..462	CDD:176069	21/91 (23%)
		STKc_PKN	614..938	CDD:270741	167/324 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930