DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	219/562 - (38%)
Similarity:	302/562 - (53%)	Gaps:	100/562 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 FTFCDHCGSLLYGL------------IKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSS 314
            ::..|.|.:|...:            .|.....|....:.||:.:.:..|.|.:..:.....|
  Fly  1335 YSSVDGCANLSASMKKKLRKEKKKQKAKAAAAAEAKRFDPHKKIKIDTTNKCYVKEEAPRYPL-- 1397

  Fly   315 LGISPDKQQPRRSKYL-------NQQGGEDNYGASLGADGDGAPG----QSFRSCALS--VDSLA 366
              ::..:...:|.|.:       ::.|.|:..|.||..|.|...|    .|..|.|.|  :|::|
  Fly  1398 --VATPRPLWKREKIVYSDENTDDESGSEEGSGGSLDEDSDDESGGEECSSTSSSASSEDLDAVA 1460

  Fly   367 -------TSTTTMTSGYNS--SSCMSLAV----TGSGG----------------------VGATG 396
                   ::.||:....||  |:..:|:|    :||||                      .|.|.
  Fly  1461 MVTKAGSSNATTVLDSSNSSGSNAGTLSVPSAGSGSGGGASTSSSPSIIRMSTCSNDSGFEGGTA 1525

  Fly   397 ETRPGKC-----------------------------SLLDFNFIKVLGKGSFGKVMLAEKKGTDE 432
            .:.|.|.                             |:.||:|:.||||||||||:|||.:.|..
  Fly  1526 PSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLAELRDTTY 1590

  Fly   433 IYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQ 497
            .||||.||||.:::|||||.|:.|:::|||...||:|..|...|||...|||||||:|||||||.
  Fly  1591 YYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFH 1655

  Fly   498 IQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGM 562
            ||::.||...||.||.||:...|:|||..|:|||||||||:|||.|||.::|||||||..|....
  Fly  1656 IQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCKLQIYLDK 1720

  Fly   563 LTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYP 627
            ...:|||||||:||||:|.::|..:||||:.|||:|||:.||.||...:|||||.||.::...:|
  Fly  1721 TADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFP 1785

  Fly   628 VWLSREAVSILKGFLTKNPEQRLGC----TGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKN 688
            |::|.||..||||.|.|:..:|:|.    .||   |..|.||..:||..||||.|:|||:|::|:
  Fly  1786 VYISAEATGILKGLLEKDYTKRIGSQYSPAGD---IADHIFFRPIDWGLLEKRQIEPPFKPQVKH 1847

  Fly   689 PRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            |.|...||..||:|...||||..|::..::|.:|.||::.||
  Fly  1848 PLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTYTNP 1889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556	9/53 (17%)
		STKc_nPKC_epsilon	412..729	CDD:270743	172/320 (54%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	144/260 (55%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	172/321 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452327
Domainoid	1	1.000	46	1.000	Domainoid score	I3535
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	206	1.000	Inparanoid score	I1276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm46471
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
	10	10.030