Protein Alignment Pkc98E and Pkn1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001186522.1
• Gene: Pkn1 / 320795
• MGIID: 108022
• Length: 951
• Species: Mus musculus
• Alignment Length: 676
• Identity: 225/676 - (33%)
• Similarity: 319/676 - (47%)
• Gaps: 163/676 - (24%)

  Fly    65 WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSETAVQDLWVNLEPQGKIH 126
            |::.|..::.....:.|.||.      .|....|.:.|   ||.:.:|.  .::.:::||||.:.
Mouse   423 WDQSFTLELERARELELAVFW------RDQRGLCALKFLKLEDFLDNER--HEVQLDMEPQGCLV 479

  Fly   127 VIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCS 191
            ..:..:|        .::|....:.::.|.   |::::|...:|..|:|..  :||::|
Mouse   480 AEVTFRN--------PIIERIPRLQRQKKI---FSKQQGKAFQRARQMNID--VATWVR------ 525

  Fly   192 HCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVV 256
                                                                             
Mouse   526 ----------------------------------------------------------------- 525

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
                          ||..||...:                ...|...|....|||..:..||.:|
Mouse   526 --------------LLRRLIPSAV----------------ATGTFSPNASPGAEIRHTGDISMEK 560

  Fly   322 QQPRRSKYLNQQGGEDNYGASLGADGDGA-----PGQSFRSCALSVDSLATSTTTMTSGYNSSSC 381
                    ||           ||||.|.:     ||....||:||..:..::|         |..
Mouse   561 --------LN-----------LGADSDSSSQKSPPGLPSTSCSLSSPTHESTT---------SPE 597

  Fly   382 MSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQ 446
            :......:.|.|.....|....:|.||.|:.|||:|.||||:|:|.:.:.|::|||.|||..|:.
Mouse   598 LPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRSSGELFAIKALKKGDIVA 662

  Fly   447 DDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRA 509
            .|:|:..|.||||||..  |.||||..|..|||||:.:.|||||..|||||..|. :..|...||
Mouse   663 RDEVESLMCEKRILAAVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRA 726

  Fly   510 AFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYI 574
            .||:|.|.|.|||||.|.::||||||||:|||.||:.|:||||:||||:..|..|:||||||:::
Mouse   727 VFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFL 791

  Fly   575 APEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILK 639
            |||:|.:..|..:||||.||||:|||:.|:.||..|:|:|:||||::|:|.||.:||.||:.|::
Mouse   792 APEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMR 856

  Fly   640 GFLTKNPEQRLGCT-GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            ..|.:|||:|||.| .|..:::|.|||..|.|..|..|.:.|||.|.:....|.:|||.|||.|.
Mouse   857 RLLRRNPERRLGSTERDAEDVKKQPFFRSLGWDVLLARRLPPPFVPTLSGRTDVSNFDEEFTGEA 921

  Fly   704 PVLTPIGN-EVVRCINQDEFAGFSFV 728
            |.|:|..: ..:....|..|..|.||
Mouse   922 PTLSPPRDARPLTAAEQAAFRDFDFV 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	15/71 (21%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	5/58 (9%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	5/53 (9%)
		STKc_nPKC_epsilon	412..729	CDD:270743	165/321 (51%)
Pkn1	NP_001186522.1	HR1_PKN_1	37..103	CDD:212012
		HR1_PKN1_2	126..197	CDD:212020
		HR1	214..286	CDD:469609
		C2_PKN-like	397..484	CDD:176069	15/68 (22%)
		STKc_PKN	624..948	CDD:270741	167/325 (51%)