Protein Alignment Pkc98E and Pkn1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_006255307.1
• Gene: Pkn1 / 29355
• RGDID: 69308
• Length: 951
• Species: Rattus norvegicus
• Alignment Length: 676
• Identity: 224/676 - (33%)
• Similarity: 319/676 - (47%)
• Gaps: 163/676 - (24%)

  Fly    65 WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSETAVQDLWVNLEPQGKIH 126
            |::.|..::.....:.|.||.      .|....|.:.|   ||.:.:|.  .::.:::||||.:.
  Rat   423 WDQSFTLELERARELELAVFW------RDQRGLCALKFLKLEDFLDNER--HEVQLDMEPQGCLV 479

  Fly   127 VIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCS 191
            ..:..:|        .::|....:.::.|.   |::::|...:|..|:|..  :||::|
  Rat   480 AEVTFRN--------PIIERIPRLQRQKKI---FSKQQGQTFQRARQMNID--VATWVR------ 525

  Fly   192 HCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVV 256
                                                                             
  Rat   526 ----------------------------------------------------------------- 525

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
                          ||..||...:                ...:...|....:||.|:..||.:|
  Rat   526 --------------LLRRLIPNAV----------------ATGSFSPNASPGSEIRSTGDISMEK 560

  Fly   322 QQPRRSKYLNQQGGEDNYGASLGADGDGA-----PGQSFRSCALSVDSLATSTTTMTSGYNSSSC 381
                    ||           ||||.|.:     .|....||:||..:..::|         |..
  Rat   561 --------LN-----------LGADSDSSSQKSPAGLPSTSCSLSSPTHESTT---------SPE 597

  Fly   382 MSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQ 446
            :......:.|.|.....|....:|.||.|:.|||:|.||||:|:|...:.|::|||.|||..|:.
  Rat   598 LPSETQETPGPGLCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFHSSGELFAIKALKKGDIVA 662

  Fly   447 DDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRA 509
            .|:|:..|.||||||..  |.||||..|..|||||:.:.|||||..|||||..|. :..|...||
  Rat   663 RDEVESLMCEKRILATVTRAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRA 726

  Fly   510 AFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYI 574
            .||:|.|.|.|||||.|.::||||||||:|||.||:.|:||||:||||:..|..|:||||||:::
  Rat   727 VFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFL 791

  Fly   575 APEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILK 639
            |||:|.:..|..:||||.||||:|||:.|:.||..|:|:|:||||::|:|.||.:||.||:.|::
  Rat   792 APEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMR 856

  Fly   640 GFLTKNPEQRLGCT-GDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            ..|.:|||:|||.| .|..:::|.|||..|||..|..|.:.|||.|.:....|.:|||.|||.|.
  Rat   857 RLLRRNPERRLGSTERDAEDVKKQPFFRTLDWDALLARRLPPPFVPTLSGRTDVSNFDEEFTGEA 921

  Fly   704 PVLTPIGN-EVVRCINQDEFAGFSFV 728
            |.|:|..: ..:....|..|..|.||
  Rat   922 PTLSPPRDARPLTAAEQAAFRDFDFV 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	15/71 (21%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	5/58 (9%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	4/53 (8%)
		STKc_nPKC_epsilon	412..729	CDD:270743	166/321 (52%)
Pkn1	XP_006255307.1	HR1_PKN_1	37..103	CDD:212012
		HR1_PKN1_2	126..197	CDD:212020
		HR1	214..286	CDD:469609
		C2_PKN-like	397..484	CDD:176069	15/68 (22%)
		STKc_PKN	624..948	CDD:270741	168/325 (52%)