DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and Prkce

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_058867.2	Gene:	Prkce / 29340	RGDID:	61925	Length:	737	Species:	Rattus norvegicus

Alignment Length:	769	Identity:	439/769 - (57%)
Similarity:	553/769 - (71%)	Gaps:	71/769 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVW 65
            :|.|.|:||:|||..|:||.:..||  ..|......|:|||::::||:|...:..|:.||..|.|
  Rat     3 VFNGLLKIKICEAVSLKPTAWSLRH--AVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAW 65

  Fly    66 NEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE 130
            :::||.||.|...|.|.|||||.:..|||||||.|.||:|:|:.:...:.|::|||:||::|||:
  Rat    66 HDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIID 130

  Fly   131 LKNRTDKAKAEAVVEHTVAVNKE--FKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            |...:.:|..:         |:|  |:||....:|:||:|||||||||||||||:|||||:||||
  Rat   131 LSGSSGEAPKD---------NEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHC 186

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM-RDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |:|||| ||||||||||||.||||:||..:::||.|: :.|.|.:|    ..|||:||:||:|.:
  Rat   187 RDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEV----GSQRFSVNMPHKFGI 247

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:||::|||||:.|.||||:||:.|||..||::.:.:|::|:.||::|||
  Rat   248 HNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDK 312

  Fly   322 --QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRS-------C-------------ALSVDS 364
              ...:|.|.| ..|.|....||     ..:|.:..||       |             |||.|:
  Rat   313 ITNSGQRRKKL-AAGAESPQPAS-----GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDN 371

  Fly   365 LATS--TTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLL---DFNFIKVLGKGSFGKVML 424
            ....  .::.|.|..:|.            |..||.|.|:...|   :|||||||||||||||||
  Rat   372 RGEEHRASSSTDGQLASP------------GENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVML 424

  Fly   425 AEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYV 489
            ||.||.||:||:||||||.|:||||||||||||||||||..||:||.|:.||||.||||||||||
  Rat   425 AELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV 489

  Fly   490 NGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMC 554
            ||||||||||::|:|:..|:.|||||||.||.|||.||||||||||||||||.||||||||||||
  Rat   490 NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC 554

  Fly   555 KEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSI 619
            ||||:||:.||||||||||||||||:|.|||.|||||||||||||||||||||||||||:||:||
  Rat   555 KEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESI 619

  Fly   620 MHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDEN---EIRKHPFFAKLDWKELEKRNIKPP 681
            :|||||||||||:|||||||.|:||||.:||||...:|   .|::||||.::||..||::.||||
  Rat   620 LHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPP 684

  Fly   682 FRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPE 735
            |:|::|..||.||||.:||:|:|:||.:...:|:.|||:||.|||:    ||.:
  Rat   685 FKPRIKTKRDVNNFDQDFTREEPILTLVDEAIVKQINQEEFKGFSY----FGED 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	60/132 (45%)
		C1_1	177..228	CDD:278556	40/51 (78%)
		C1_1	252..304	CDD:278556	34/51 (67%)
		STKc_nPKC_epsilon	412..729	CDD:270743	240/319 (75%)
Prkce	NP_058867.2	C2_PKC_epsilon	3..135	CDD:175981	60/133 (45%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	50/62 (81%)
		Interaction with actin. /evidence=ECO:0000250	223..228		0/4 (0%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	35/53 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..356		14/51 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..398		8/40 (20%)
		STKc_nPKC_epsilon	412..732	CDD:270743	240/323 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I535
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48343
Inparanoid	1	1.050	865	1.000	Inparanoid score	I401
OMA	1	1.010	-	-		QHG51944
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm44622
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980