DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Pkn3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_030107417.1	Gene:	Pkn3 / 263803	MGIID:	2388285	Length:	914	Species:	Mus musculus

Alignment Length:	772	Identity:	229/772 - (29%)
Similarity:	330/772 - (42%)	Gaps:	209/772 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TGKLQIKV--CE--------------------ASGLRPTDFQKRHNLTFGKLADEQL----IDPY 41
            ||.||:::  |:                    .|.||....|:|..   |:||.|.|    :|..
Mouse   307 TGTLQVRLLGCKDLLVAVPGRSPMAVLAGSPSESWLRTRSRQQRGG---GELASEVLAVLKVDNR 368

  Fly    42 VSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---E 103
            |   |.::.:.....:.      |::.|:..:.....:.:.|..      .|:...|.::|   |
Mouse   369 V---VGQTGWGLVAEKS------WDQSFIISLDRARELEIGVHW------RDWRQLCGVAFLKLE 418

  Fly   104 DLMQSETAVQDLWVNLEPQGKIHVIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMR 168
            |.:  :.|...|.::|.|||::...:..        .|.|:|....:.   ::|..|::|||...
Mouse   419 DFL--DNACHQLSLSLVPQGRLFAQVTF--------CEPVIERRPRLQ---RQRCIFSKRRGRDF 470

  Fly   169 RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQ 233
            .|..|:|  ..||.               ||                 :..:|::..|.......
Mouse   471 MRASQMN--LSMAA---------------WG-----------------RLVMSLLPPCSSPNTAS 501

  Fly   234 PAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVA 298
            |      |.|:      |...|            ||:.........|..:|
Mouse   502 P------PKGR------PSTAV------------CGTPSAASPSNFLPMKT-------------- 528

  Fly   299 NTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCA---- 359
                         ||.....|..:.||  .||.:.                |||   ..|.
Mouse   529 -------------LSKEDTKPPPKPPR--LYLQEP----------------APG---TPCTKRPH 559

  Fly   360 -----LSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSF 419
                 ..|.:||..:|                           .:|.:  |.||..:.|||:|.|
Mouse   560 MDPRPAVVPALAALST---------------------------RKPPR--LQDFRCLAVLGRGHF 595

  Fly   420 GKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRL 482
            |||:|.:.|||.:.||||.|||..::..|::|....|||||...  ..||||.:|.:|.||....
Mouse   596 GKVLLVQYKGTGKYYAIKALKKQEVLGRDEIDSLYCEKRILETVGRTGHPFLLSLLACLQTSSHA 660

  Fly   483 FFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCK 547
            .||.|::.|||||.||.: ..|...:|.||.|.|.|.|||||...:|||||||||:|||.:|..|
Mouse   661 CFVTEFLPGGDLMAQIHE-DVFPEPQACFYLACVVLGLQFLHEKRIIYRDLKLDNLLLDAQGFLK 724

  Fly   548 LADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNE 612
            :||||:|||||..|..|:||||||:::|||:|.::.|..:||||.||||:|||:.|:.||..|.|
Mouse   725 IADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTE 789

  Fly   613 DELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAKLDWKELEKR 676
            :|:|:.|:..||..|.:||.:.:.:::..|.|:||:|||. ..|..||:..|||...:|:.|..|
Mouse   790 EEVFECIVSADVPCPHFLSVQGLELIQKLLQKSPEKRLGAGERDAEEIKVQPFFRTTNWQALLAR 854

  Fly   677 NIKPPFRPKMKNPRDANNFDAEFTKEDPVLT-PIGNEVVRCINQDEFAGFSFVNPKF 732
            .::|||.|.:..|.|...|:.|||...|.|| |:....:....|..|..|.||:.:|
Mouse   855 TVQPPFVPTLCGPADLRYFEGEFTSLPPTLTPPVSQSSLTARQQAAFRDFDFVSEQF 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	32/159 (20%)
		C1_1	177..228	CDD:278556	6/50 (12%)
		C1_1	252..304	CDD:278556	5/51 (10%)
		STKc_nPKC_epsilon	412..729	CDD:270743	150/320 (47%)
Pkn3	XP_030107417.1	HR1_PKN_1	23..88	CDD:212012
		HR1	103..176	CDD:381797
		HR1	203..>257	CDD:381797
		C2	357..444	CDD:387358	19/103 (18%)
		STKc_PKN	584..909	CDD:270741	152/325 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840