DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc98E and Aurka

DIOPT Version :10

Sequence 1:NP_524545.2 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_695208.2 Gene:Aurka / 261730 RGDID:628895 Length:397 Species:Rattus norvegicus


Alignment Length:468 Identity:130/468 - (27%)
Similarity:200/468 - (42%) Gaps:89/468 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   217 KCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQ 281
            :|..:.||:        |.| ..||.|       |.|.:|...   ....|.||...|..::.| 
  Rat     3 RCKENCVSR--------PVK-STVPFG-------PKRVLVTEQ---IPSQHPGSASSGQAQRVL- 47

  Fly   282 CETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPR-RSKYLNQQGGEDNYGASLGA 345
            |.:....|..:.||.||.        ...:|..|   |....|| .|:..|.|..|....|:   
  Rat    48 CPSNSQRVPPQAQKPVAG--------QKPVLKQL---PAASGPRPASRLSNPQKSEQPQPAA--- 98

  Fly   346 DGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNF 410
                                        ||.||....:       .:..|.:::..:.:|.||:.
  Rat    99 ----------------------------SGNNSEKEQT-------SIQKTEDSKKRQWTLEDFDI 128

  Fly   411 IKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAAN--HPFLTALH 473
            .:.||||.||.|.||.:|.:..|.|:|||.|   :|.:........:|.:.:.::  ||.:..|:
  Rat   129 GRPLGKGKFGNVYLAREKQSKFILALKVLFK---VQLEKAGVEHQLRREVEIQSHLRHPNILRLY 190

  Fly   474 SCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNI 538
            ..|....|::.::||...|.:..::||..:|:..|.|.|..|:..||.:.|:..||:||:|.:|:
  Rat   191 GYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENL 255

  Fly   539 LLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAG 603
            ||...|..|:||||.....  .....||.|||.||:.||:::.:.:...||.|:||||.||.:.|
  Rat   256 LLGSNGELKIADFGWSVHA--PSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG 318

  Fly   604 QPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAKL 668
            .|||||....|.:..|...:..:|.:::..|..::...|..|..|||...    |:.:||     
  Rat   319 MPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNSSQRLTLA----EVLEHP----- 374

  Fly   669 DWKELEKRNIKPP 681
             |  ::..:.|||
  Rat   375 -W--IKANSSKPP 384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc98ENP_524545.2 C2_PKC_epsilon 1..134 CDD:175981
C1_nPKC_epsilon-like_rpt1 171..230 CDD:410385 3/12 (25%)
C1_nPKC_epsilon-like_rpt2 250..304 CDD:410388 14/53 (26%)
STKc_nPKC_epsilon 412..729 CDD:270743 90/272 (33%)
AurkaNP_695208.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..118 37/183 (20%)
STKc_Aurora-A 120..376 CDD:271018 90/272 (33%)
Activation segment. /evidence=ECO:0000250|UniProtKB:O14965 273..286 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..397 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

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