DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and pck2

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_595950.1	Gene:	pck2 / 2539649	PomBaseID:	SPBC12D12.04c	Length:	1016	Species:	Schizosaccharomyces pombe

Alignment Length:	840	Identity:	281/840 - (33%)
Similarity:	419/840 - (49%)	Gaps:	172/840 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQFVHDVTNVSN 78
            |||.........|:|......:| .:..|:|..::  .:||.|||...|. :||.|..|:...:.
pombe   210 SGLLKITVGSLRNVTHSAGISKQ-TEMIVAIRAED--LERARTRPSRTDR-FNETFEIDLEKTNE 270

  Fly    79 INLTVF---HDAALPPDDFVANCIISFEDLMQS------ETAVQD-------------------- 114
            :.:.|:   ::..|.|   |....|...||::.      |..|.|
pombe   271 VEIVVYEKKNEKLLLP---VGLLWIRLSDLVEKQRRKKVEQEVSDKGWVSADKMINQRLSIFLPS 332

  Fly   115 ------------------------LWVNLEPQGKIHVIIEL-KNRTDKAKAEAVVEHTVAVNKEF 154
                                    .|.:|||.|:|::.:.. |:.|.|...:
pombe   333 ALNNISKPESTDRPNTASGNQSVSAWFSLEPMGQINLTMNFTKHNTRKRPMD------------- 384

  Fly   155 KERAGFNRRRGAMRRR---VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHK 216
               ||.. |:||:|:|   ||:|.||||:.....|...|:.|.||:....  |.||..|....||
pombe   385 ---AGLG-RQGAIRQRKESVHEVYGHKFLQHQFYQIMRCALCGEFLKNAA--GMQCIDCHYTCHK 443

  Fly   217 KCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQ 281
            ||:..||:||.. :....|..|.    ::.|..:||.|..|:.....:|.|||.:|....|...:
pombe   444 KCYPKVVTKCIS-KSSDSASSEY----EKINHRIPHHFESHTNIGANWCCHCGYILPLGRKTARK 503

  Fly   282 CETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGIS------PDKQQPRRSKYLNQQGGEDNYG 340
            |..||:..|.:|...|.:.||::.:....::|.:..:      ..||:....|:.:.:..:.:
pombe   504 CTECGITAHAQCVHLVPDFCGMSMEMANRVISEIRTTKIYKAQQHKQKSSHHKHHHHKKSKSS-- 566

  Fly   341 ASLGADGDGAPGQSFRSCALSVDSLATSTTTMT-SGYNSSSCMSLAV-----------------T 387
            :|...:.|.|          ||....|:|.::| :....:|...||:                 .
pombe   567 SSKHKENDKA----------SVSITTTTTPSITPADPVPTSPKPLAIEPVKRKPVHAGNLEVTSV 621

  Fly   388 GSGGVGATGE-------------TRP----------------------------GKCSLLDFNFI 411
            ....:|||.:             |:|                            .:..|.||.|:
pombe   622 SDNKLGATVQVVEQKVDDKADALTKPPSLDAVKEPIPVPSVETSVVAQDLTHKAKRIGLEDFTFL 686

  Fly   412 KVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAAN---HPFLTALH 473
            .|||||:||||||||.|...::||||||||:.|:::|:|:.|.:|||:. |.||   ||||..||
pombe   687 SVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVESTKSEKRVF-LVANRERHPFLVNLH 750

  Fly   474 SCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNI 538
            |||||..|::|||::|:|||||..||: .:|...||.||||||.|||::.|.:|:||||||||||
pombe   751 SCFQTETRIYFVMDFVSGGDLMLHIQQ-EQFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNI 814

  Fly   539 LLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAG 603
            ||..:||.|:||:|:|||.:.:...|.||||||:::|||||.||:|..||||||.|||:|:|:.|
pombe   815 LLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEILLEQQYTRSVDWWAFGVLIYQMLLG 879

  Fly   604 QPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAK 667
            |.||..::|:|:||:|:.|:.|||:.:.|::||||:..||::|::|||. ..|..::..||||:.
pombe   880 QSPFRGEDEEEIFDAILSDEPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPNDAEDVMTHPFFSN 944

  Fly   668 LDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSF 727
            ::|.::..:..:||:.|.:.:|.|...||.|||:|.|||||: |.::....|..|.|||:
pombe   945 INWDDIYHKRTQPPYIPSLNSPTDTKYFDEEFTRELPVLTPV-NSILTKEMQQHFEGFSY 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	35/173 (20%)
		C1_1	177..228	CDD:278556	20/50 (40%)
		C1_1	252..304	CDD:278556	17/51 (33%)
		STKc_nPKC_epsilon	412..729	CDD:270743	168/320 (53%)
pck2	NP_595950.1	HR1_PKC-like_1_fungi	2..73	CDD:212011
		HR1_PKC-like_2_fungi	115..186	CDD:212010
		C2_fungal_Pkc1p	213..320	CDD:176071	25/113 (22%)
		C1_1	406..454	CDD:278556	19/49 (39%)
		C1_1	474..526	CDD:278556	17/51 (33%)
		S_TKc	683..942	CDD:214567	145/260 (56%)
		STKc_PKC	688..1003	CDD:270722	167/317 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	46	1.000	Domainoid score	I3535
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48343
Inparanoid	1	1.050	437	1.000	Inparanoid score	I315
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		mtm9272
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
TreeFam	0	0.000	Not matched by this tool.
	12	11.890