Protein Alignment Pkc98E and Prkcb

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_036845.3
• Gene: Prkcb / 25023
• RGDID: 3396
• Length: 673
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 315/680 - (46%)
• Similarity: 404/680 - (59%)
• Gaps: 134/680 - (19%)

  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            |:||:|:: ||:|..|||.|.|.:||||||||.:||||:|.||:|.|||..||||:||..|...|
  Rat    22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGLGLQGFQSQVCCFVVHKRCHEFVTFSC 86

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291
            || .|:.||..:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|||||
  Rat    87 PG-ADKGPASDD--PRSK-------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHK 141

  Fly   292 RCQKNVANTCGI-NTKQMAEI----------------------------LS----SLGISPDKQQ 323
            ||..||.:.||. :|::...|                            ||    .|.:.||.:.
  Rat   142 RCVMNVPSLCGTDHTERRGRIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206

  Fly   324 PRRSK------YLNQQGGED---------------------------------NYGAS----LGA 345
            ..:.|      .||.:..|.                                 ::|.|    .|.
  Rat   207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGV 271

  Fly   346 DG-------------------DGAPG-----QSFRSCALSVDSLA--TSTTTMTSGYNSSSCMSL 384
            ||                   :|:.|     |.|....:...:.|  ..|....|.::::.
  Rat   272 DGWFKLLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNG---- 332

  Fly   385 AVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDD 449
                          ...:..|.||||:.||||||||||||:|:|||||:||:|:||||.:|||||
  Rat   333 --------------NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD 383

  Fly   450 VDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAA 514
            |:|||.|||:|||....||||.|||||||.|||:||||||||||||:.||:..||:...|.||||
  Rat   384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448

  Fly   515 EVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEIL 579
            |:.:.|.||.:.|:|||||||||::||.|||.|:||||||||.|.:|:.|.|||||||||||||:
  Rat   449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513

  Fly   580 KEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTK 644
            ..|.||.||||||.|||:|||:|||.|||.::|||||.|||..:|.||..:|:|||:|.||.:||
  Rat   514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578

  Fly   645 NPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTP 708
            :|.:||||..: |.:|::|.||..:||::||::.|:||::||... |:|.|||..||:..|||||
  Rat   579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFTRHPPVLTP 642

  Fly   709 IGNEVVRCINQDEFAGFSFVNPKF-GPERK 737
            ...||:|.|:|.||.||||||.:| .||.|
  Rat   643 PDQEVIRNIDQSEFEGFSFVNSEFLKPEVK 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	37/58 (64%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	34/54 (63%)
		STKc_nPKC_epsilon	412..729	CDD:270743	202/317 (64%)
Prkcb	NP_036845.3	C1_cPKC_rpt1	35..92	CDD:410383	35/57 (61%)
		C1_cPKC_rpt2	102..155	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	15/129 (12%)
		STKc_cPKC_beta	341..663	CDD:270767	206/322 (64%)