DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Prkcg

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_036760.1	Gene:	Prkcg / 24681	RGDID:	3397	Length:	697	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	308/691 - (44%)
Similarity:	392/691 - (56%)	Gaps:	152/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            |:||:|:: ||:|..|||.|.|.:||||||||.:|||||||||.|||||:.|||::||..|..:|
  Rat    21 RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFEC 85

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLP---HRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMN 288
            ||             ||:....:.|   |:|.:|||...|||||||||||||:.||::|..|.||
  Rat    86 PG-------------AGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMN 137

  Fly   289 VHKRCQKNVANTCGIN------------------------------------------------- 304
            ||:||.::|.:.||::
  Rat   138 VHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIP 202

  Fly   305 -----TKQMAEILSS-----------LGISPDKQQPRRS-------------------------- 327
                 |||..:.:.:           ..:.|...:.|.|
  Rat   203 DPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELL 267

  Fly   328 --------KYLNQQGGEDNYGASLGADGDGAP-GQSFRSCALSVD---------SLATSTTTMTS 374
                    |.|||:.|| .|...: ||.|... .|.|.:|...::         |.:...:...|
  Rat   268 KAPVDGWYKLLNQEEGE-YYNVPV-ADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPS 330

  Fly   375 GYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVL 439
            ..:|..|.         .||:    ||:..:.||:|:.||||||||||||||::|:||:||||:|
  Rat   331 PTDSKRCF---------FGAS----PGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKIL 382

  Fly   440 KKDAIIQDDDVDCTMTEKRILALAANHP-----FLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQ 499
            |||.|:||||||||:.|||:|||....|     |||.|||.|||||||:||||||.|||||:.||
  Rat   383 KKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQ 447

  Fly   500 KARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLT 564
            :..:|:...|||||||:.:.|.|||..|:|||||||||::||.|||.|:.|||||||.:..|..|
  Rat   448 QLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTT 512

  Fly   565 TTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVW 629
            .|||||||||||||:..|.||.|||||:.|||:|||:||||||:.::|:|||.:||...|.||..
  Rat   513 RTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKS 577

  Fly   630 LSREAVSILKGFLTKNPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNP--RD 691
            ||||||:|.||||||:|.:|||...| |..||.|.||..:||:.||:..|.|||||:   |  |.
  Rat   578 LSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIAPPFRPR---PCGRS 639

  Fly   692 ANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
            ..|||..||:..|.|||....|:..|:|.:|.||::|||.|
  Rat   640 GENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDF 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	34/50 (68%)
		C1_1	252..304	CDD:278556	31/51 (61%)
		STKc_nPKC_epsilon	412..729	CDD:270743	197/324 (61%)
Prkcg	NP_036760.1	C1_cPKC_rpt1	34..91	CDD:410383	38/69 (55%)
		C1_cPKC_rpt2	101..154	CDD:410386	31/52 (60%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	13/131 (10%)
		STKc_cPKC	354..677	CDD:270739	197/325 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920