Protein Alignment Pkc98E and Prkca

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: XP_038941139.1
• Gene: Prkca / 24680
• RGDID: 3395
• Length: 722
• Species: Rattus norvegicus
• Alignment Length: 715
• Identity: 318/715 - (44%)
• Similarity: 408/715 - (57%)
• Gaps: 162/715 - (22%)

  Fly   161 NR--RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSV 222
            ||  |:||:|:: ||:|..|||:|.|.:||||||||.:||||.||||:|||||..||||:||..|
  Rat    18 NRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFV 82

  Fly   223 VSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGM 287
            ...||| .|:.|...:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|
  Rat    83 TFSCPG-ADKGPDTDD--PRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDM 137

  Fly   288 NVHKRCQKNVANTCGINTKQ-------MAEILS--------------------------SLGISP 319
            ||||:|..||.:.||::..:       .||:..                          .|.:.|
  Rat   138 NVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIP 202

  Fly   320 DKQQPRRSK------YLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTS---- 374
            |.:...:.|      .||.|..|........:|.|.         .|||:......||...
  Rat   203 DPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDR---------RLSVEIWDWDRTTRNDFMGS 258

  Fly   375 -GYNSSSCMSLAVTG----------------------SGGV-----------GATG-------ET 398
             .:..|..|.:..:|                      .|.|           |..|       |.
  Rat   259 LSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSED 323

  Fly   399 RP------GKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEK 457
            |.      .:..|.||||:.|||||||||||||::|||:|:||||:||||.:||||||:|||.||
  Rat   324 RKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEK 388

  Fly   458 RILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQF 522
            |:|||....||||.|||||||.|||:||||||||||||:.||:..:|:..:|.|||||:::.|.|
  Rat   389 RVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFF 453

  Fly   523 LHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGAS 587
            ||..|:|||||||||::||.|||.|:||||||||.:|:|:.|.|||||||||||||:..|.||.|
  Rat   454 LHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKS 518

  Fly   588 VDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC 652
            |||||.|||:|||:||||||:.::|||||.|||..:|.||..||:|||||.||.:||:|.:||||
  Rat   519 VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGC 583

  Fly   653 TGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMK------------------------NP--- 689
            ..: |.::|:|.||.::||::||.|.|:|||:||::                        :|
  Rat   584 GPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVQCTAEVRGFTAFSTQLFLILDISNSSPLSV 648

  Fly   690 ----------------------RDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
                                  :.|.|||..||:..|||||....|:..|:|.:|.|||:|||:|
  Rat   649 LILQNFCTKMHWLQWASRPSCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQF 713

  Fly   733  732
              Rat   714  713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	39/58 (67%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	33/53 (62%)
		STKc_nPKC_epsilon	412..729	CDD:270743	202/366 (55%)
Prkca	XP_038941139.1	C1_cPKC_rpt1	35..92	CDD:410383	37/57 (65%)
		C1_cPKC_rpt2	102..155	CDD:410386	33/52 (63%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	20/138 (14%)
		Protein Kinases, catalytic domain	328..718	CDD:473864	211/386 (55%)