DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Akt1

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_150233.1	Gene:	Akt1 / 24185	RGDID:	2081	Length:	480	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	153/332 - (46%)
Similarity:	229/332 - (68%)	Gaps:	7/332 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 KCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANH 466
            :.::.:|.::|:||||:||||:|.::|.|...||:|:|||:.|:..|:|..|:||.|:|. .:.|
  Rat   144 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQ-NSRH 207

  Fly   467 PFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTH-GVIY 530
            ||||||...|||.|||.|||||.|||:|.|.:.:.|.|...||.||.||:..||.:||:. .|:|
  Rat   208 PFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVY 272

  Fly   531 RDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGV 595
            |||||:|::||::||.|:.|||:|||||.:|....||||||:|:|||:|::.:||.:||||.|||
  Rat   273 RDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV 337

  Fly   596 LMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRL-GCTGDENEI 659
            :|||||.|:.||...:.::||:.|:.:::.:|..|..||.|:|.|.|.|:|.||| |.:.|..||
  Rat   338 VMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEI 402

  Fly   660 RKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIG-NEVVRCINQD--- 720
            .:|.|||.:.|:::.::.:.|||:|::.:..|...||.|||.:...:||.. ::.:.|::.:
  Rat   403 MQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRP 467

  Fly   721 EFAGFSF 727
            .|..||:
  Rat   468 HFPQFSY 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	152/322 (47%)
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		STKc_PKB_alpha	124..479	CDD:270746	153/332 (46%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..480		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910