DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Pkn2

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_038957612.1	Gene:	Pkn2 / 207122	RGDID:	620146	Length:	989	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	228/700 - (32%)
Similarity:	325/700 - (46%)	Gaps:	172/700 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 WNEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISF---EDLMQSETAVQDLWVNLEPQGKIH 126
            |:::|..::.....:.::|:.      .|:.:.|.:.|   ||.:.::.  ..:.:.|||||.:.
  Rat   422 WDQKFTLELDRSRELEISVYW------RDWRSLCAVKFLRLEDFLDNQR--HGMCLYLEPQGTLF 478

  Fly   127 VIIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCS 191
            ..:...|        .|:|....:.::.|.   |::::|               .||||.|..
  Rat   479 AEVTFFN--------PVIERRPKLQRQKKI---FSKQQG---------------KTFLRAPQM-- 515

  Fly   192 HCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            :.....||        ::....:....|....|.    :...||.|.:|.|
  Rat   516 NINIATWG--------RLVRRAIPTVNHSGTFSP----QTPVPATVPVVDA-------------- 554

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILS-------S 314
                                                           .|.::|...|       .
  Rat   555 -----------------------------------------------RTPELAPPASDSTVTKLD 572

  Fly   315 LGISPD--KQQPRRSKYLNQQGGEDNYGASLGADGDGA-------PGQSFRSCALSVDSLATSTT 370
            ..:.|:  ...||.|              |||...|.:       |||.    :.:|..:.....
  Rat   573 FDLEPEAPPAPPRAS--------------SLGEIDDSSELRVLDIPGQG----SETVFDIENDRN 619

  Fly   371 TM----TSGY------NSSSCMSLAVTGSGGVGATGETRPG---KCSLLDFNFIKVLGKGSFGKV 422
            .|    .|.|      :|.||.|        ||...:.|..   :.:|.||....|||:|.||||
  Rat   620 NMRPKSKSEYELNIPDSSRSCWS--------VGELEDKRSQQRFQFNLQDFRCCAVLGRGHFGKV 676

  Fly   423 MLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILAL--AANHPFLTALHSCFQTPDRLFFV 485
            :|||.|.|:|::|||.|||..|:..|:||..|.||||...  :..||||..|.:||||.:.:.||
  Rat   677 LLAEYKHTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFV 741

  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550
            |||..|||||..|. ...|...||.||||.|.|.||:||.|.::||||||||:|||.||..|:||
  Rat   742 MEYAAGGDLMMHIH-TDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIAD 805

  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDEL 615
            ||:||||:..|..|:||||||:::|||:|.|..|..:||||.||||:|||:.|:.||..|:|:|:
  Rat   806 FGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV 870

  Fly   616 FDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC-TGDENEIRKHPFFAKLDWKELEKRNIK 679
            ||||::|:|.||.:||.||:||::..|.:|||:|||. ..|..:::|||||...||..|..:.:|
  Rat   871 FDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGAGEKDAEDVKKHPFFRLTDWSALLDKKVK 935

  Fly   680 PPFRPKMKNPRDANNFDAEFTKEDPVLTPIGN-EVVRCINQDEFAGFSFV 728
            |||.|.::...|.:|||.|||.|.|:|||... .::....|:.|..|.:|
  Rat   936 PPFVPTIRGREDVSNFDDEFTSEAPILTPPREPRILLEEEQEMFRDFDYV 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	13/71 (18%)
		C1_1	177..228	CDD:278556	9/50 (18%)
		C1_1	252..304	CDD:278556	0/51 (0%)
		STKc_nPKC_epsilon	412..729	CDD:270743	166/320 (52%)
Pkn2	XP_038957612.1	HR1_PKN_1	48..113	CDD:212012
		HR1_PKN2_2	134..207	CDD:212021
		HR1_PKN2_3	215..288	CDD:212025
		C2_PKN-like	395..478	CDD:176069	13/63 (21%)
		STKc_PKN	662..987	CDD:270741	167/324 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810