DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Prkcq

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_032885.1	Gene:	Prkcq / 18761	MGIID:	97601	Length:	707	Species:	Mus musculus

Alignment Length:	728	Identity:	308/728 - (42%)
Similarity:	425/728 - (58%)	Gaps:	84/728 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QLIDPYVSIDVDE----SHFDRATTRPKTFDPVWNEQFVHDVTN-------VSNINLTVFHDAAL 89
            :.::||.::.|.|    .:......:..|..|.|:..|...:..       |...|:.:..:..:
Mouse    23 EAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTV 87

  Fly    90 PPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKI----HVIIELKNRTDKAKAEAVVEHTVAV 150
            .        :.|..:..:......::|:.|:|||::    ...:|:.:..|.:
Mouse    88 E--------LYSLAERCRKNNGRTEIWLELKPQGRMLMNARYFLEMSDTKDMS------------ 132

  Fly   151 NKEFKERAGF---NRRRGAMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCT 211
              || |..||   ::||||::: :||.|..|:|.|||..||||||.|.||:||:.||||||:.|.
Mouse   133 --EF-ENEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCN 194

  Fly   212 LVVHKKCHLSVVSKCPG----MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLL 272
            ..:||||...|::||.|    .|:....|       :||.:::||||.|::||..|||:|||:||
Mouse   195 AAIHKKCIDKVIAKCTGSAINSRETMFHK-------ERFKIDMPHRFKVYNYKSPTFCEHCGTLL 252

  Fly   273 YGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGED 337
            :||.:|||:|:.||||||.|||..|||.||||.|.|||.|:.:..:...:..|.|:::.::|
Mouse   253 WGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARSLRDSEHIFREG--- 314

  Fly   338 NYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPG- 401
                         |.:....|  |..:........|.|......:|......|...:.|...|.
Mouse   315 -------------PVEIGLPC--STKNETRPPCVPTPGKREPQGISWDSPLDGSNKSAGPPEPEV 364

  Fly   402 ---------KCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEK 457
                     |..:.||...|:|||||||||.|||.|.|::.:|||.||||.::.||||:|||.||
Mouse   365 SMRRTSLQLKLKIDDFILHKMLGKGSFGKVFLAEFKRTNQFFAIKALKKDVVLMDDDVECTMVEK 429

  Fly   458 RILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQF 522
            |:|:||..|||||.:...|||.:.|||||||:||||||:.||...:|:.|||.||||||.|.|||
Mouse   430 RVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQF 494

  Fly   523 LHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGAS 587
            ||:.|::||||||||||||::||.|:||||||||.::....|.||||||||||||||..|:|..|
Mouse   495 LHSKGIVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHS 559

  Fly   588 VDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC 652
            ||||:.|||:|||:.||.||...:|:|||.||..|:..||.||.|||..:|.....:.||:|||.
Mouse   560 VDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV 624

  Fly   653 TGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCI 717
            .||   ||:||.|.:::|:|||::.|.||||||:|:|.|.:|||.||..|.|.|:.....::..:
Mouse   625 RGD---IRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRALINSM 686

  Fly   718 NQDEFAGFSFVNP 730
            :|:.|:.|||:||
Mouse   687 DQNMFSNFSFINP 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	17/112 (15%)
		C1_1	177..228	CDD:278556	30/50 (60%)
		C1_1	252..304	CDD:278556	34/51 (67%)
		STKc_nPKC_epsilon	412..729	CDD:270743	184/316 (58%)
Prkcq	NP_032885.1	C1_1	160..212	CDD:278556	30/51 (59%)
		C1_1	232..284	CDD:278556	34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..365		6/37 (16%)
		STKc_nPKC_theta	374..704	CDD:270770	189/329 (57%)
		S_TKc	380..634	CDD:214567	157/256 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7921
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840