DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc98E and Prkci

DIOPT Version :10

Sequence 1:NP_524545.2 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_032883.2 Gene:Prkci / 18759 MGIID:99260 Length:595 Species:Mus musculus


Alignment Length:581 Identity:231/581 - (39%)
Similarity:312/581 - (53%) Gaps:133/581 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 RRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226
            ||||.| |:::..|||.|.|....:...|:.|.:.|||:|:|||:|..|.|:||||||..|..:|
Mouse   126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIEC 190

  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291
            .  |...|.: .|:|..|          .:|.       ||..:::                   
Mouse   191 G--RHSLPPE-PMMPMDQ----------TMHP-------DHTQTVI------------------- 216

  Fly   292 RCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFR 356
                                         ...|...:.|:|.|.|..                  
Mouse   217 -----------------------------PYNPSSHESLDQVGEEKE------------------ 234

  Fly   357 SCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGK 421
                       :..|..||..|||                      ..|.||:.::|:|:||:.|
Mouse   235 -----------AMNTRESGKASSS----------------------LGLQDFDLLRVIGRGSYAK 266

  Fly   422 VMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVM 486
            |:|...|.||.|||:||:||:.:..|:|:|...|||.:...|:|||||..|||||||..|||||:
Mouse   267 VLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVI 331

  Fly   487 EYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADF 551
            ||||||||||.:|:.|:.....|.||:||::|||.:||..|:|||||||||:|||.|||.||.|:
Mouse   332 EYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY 396

  Fly   552 GMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFE----ADN- 611
            ||||||:..|..|:||||||:|||||||:.::||.|||||||||||:|||||:.||:    :|| 
Mouse   397 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNP 461

  Fly   612 ----EDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGC---TGDENEIRKHPFFAKLD 669
                ||.||..|:...:..|..||.:|.|:||.||.|:|::||||   ||.. :|:.||||..:|
Mouse   462 DQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFA-DIQGHPFFRNVD 525

  Fly   670 WKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            |..:|::.:.|||:|.:......:|||::||.|...|||..:::||.|:|.||.||.::||
Mouse   526 WDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINP 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc98ENP_524545.2 C2_PKC_epsilon 1..134 CDD:175981
C1_nPKC_epsilon-like_rpt1 171..230 CDD:410385 25/58 (43%)
C1_nPKC_epsilon-like_rpt2 250..304 CDD:410388 3/53 (6%)
STKc_nPKC_epsilon 412..729 CDD:270743 176/328 (54%)
PrkciNP_032883.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Regulatory domain. /evidence=ECO:0000250 2..252 51/244 (21%)
Required for interaction with RAB2. /evidence=ECO:0000250 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A. /evidence=ECO:0000250 72..91
Pseudosubstrate 125..134 5/7 (71%)
C1_aPKC 139..193 CDD:410344 25/55 (45%)
STKc_aPKC_iota 232..595 CDD:270769 188/407 (46%)
Blue background indicates that the domain is not in the aligned region.

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