DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and Prkch

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_032882.2	Gene:	Prkch / 18755	MGIID:	97600	Length:	683	Species:	Mus musculus

Alignment Length:	743	Identity:	395/743 - (53%)
Similarity:	510/743 - (68%)	Gaps:	83/743 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::::.||.||:||.:..||:| |.|  ..||:|||:::.||:....:.:|:.||..|.:|
Mouse     8 FNGYLRVRIGEAVGLQPTRWSLRHSL-FKK--GHQLLDPYLTVSVDQVRVGQTSTKQKTNKPTYN 69

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQ----SETAVQDLWVNLEPQGKIHV 127
            |:|..:||:..::.|.|||:..|..|.|||||.:.|::|::    |:|.  :.||:|||:||:.|
Mouse    70 EEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTAGTSDTF--EGWVDLEPEGKVFV 132

  Fly   128 IIELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRR-GAMRRRVHQVNGHKFMATFLRQPTFCS 191
            :|.|..        :..|.|:..::.||.   |.|:| .|||||||||||||||||:|||||:||
Mouse   133 VITLTG--------SFTEATLQRDRIFKH---FTRKRQRAMRRRVHQVNGHKFMATYLRQPTYCS 186

  Fly   192 HCREFIWGI-GKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFV 255
            ||||||||: |||||||||||.||||:||..:|:.|....:..  ||:...|.|||.:|:||:|.
Mouse   187 HCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNIN--KVDAKIAEQRFGINIPHKFN 249

  Fly   256 VHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPD 320
            ||:||..||||||||||:|:::|||||:.|.||||.|||.|||..||:|..::|:.|:.:|:.|.
Mouse   250 VHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPG 314

  Fly   321 KQQPRRSKY-----LNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSS 380
            ...| .||.     |.:||.|.:      .:|:|.                        |.||||
Mouse   315 NISP-TSKLISRSTLRRQGKEGS------KEGNGI------------------------GVNSSS 348

  Fly   381 CMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII 445
                                 :..:.:|.||:|||||||||||||..|.|.|:||:||||||.|:
Mouse   349 ---------------------RFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVIL 392

  Fly   446 QDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAA 510
            |||||:|||||||||:||.||||||.|..|||||||||||||:||||||||.|||:|||:.:||.
Mouse   393 QDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARAR 457

  Fly   511 FYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIA 575
            |||||:..||.|||..|:|||||||||:|||.||||||||||||||||.||:.|.||||||||||
Mouse   458 FYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIA 522

  Fly   576 PEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKG 640
            ||||:|..||.:|||||:|||:|||:.|..||||:|||:||::|::|:|:||.||..:|..|||.
Mouse   523 PEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKS 587

  Fly   641 FLTKNPEQRLG--CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKED 703
            |:||||..|||  ..|.|:||.:||||.::||.:|..|.::|||||::|:..|.:|||.:|.||:
Mouse   588 FMTKNPTMRLGSLTQGGEHEILRHPFFKEIDWAQLNHRQLEPPFRPRIKSREDVSNFDPDFIKEE 652

  Fly   704 PVLTPIGNEVVRCINQDEFAGFSFVNPK 731
            ||||||....:..||||||..||:|:|:
Mouse   653 PVLTPIDEGHLPMINQDEFRNFSYVSPE 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	55/135 (41%)
		C1_1	177..228	CDD:278556	40/51 (78%)
		C1_1	252..304	CDD:278556	35/51 (69%)
		STKc_nPKC_epsilon	412..729	CDD:270743	215/318 (68%)
Prkch	NP_032882.2	C2_PKC_epsilon	8..140	CDD:175981	55/144 (38%)
		C1_1	172..222	CDD:365894	39/49 (80%)
		C1_1	246..296	CDD:365894	33/49 (67%)
		STKc_nPKC_eta	359..681	CDD:270742	217/322 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6913
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	873	1.000	Inparanoid score	I410
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm42557
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860