DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pkc98E and Prkce

DIOPT Version :9

Sequence 1:NP_001287577.1 Gene:Pkc98E / 43428 FlyBaseID:FBgn0003093 Length:739 Species:Drosophila melanogaster
Sequence 2:NP_035234.1 Gene:Prkce / 18754 MGIID:97599 Length:737 Species:Mus musculus


Alignment Length:769 Identity:440/769 - (57%)
Similarity:554/769 - (72%) Gaps:71/769 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVW 65
            :|.|.|:||:|||..|:||.:..||  ..|......|:|||::::||:|...:..|:.||..|.|
Mouse     3 VFNGLLKIKICEAVSLKPTAWSLRH--AVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAW 65

  Fly    66 NEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE 130
            :::||.||.|...|.|.|||||.:..|||||||.|.||:|:|:.:...:.|::|||:||::|||:
Mouse    66 HDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIID 130

  Fly   131 LKNRTDKAKAEAVVEHTVAVNKE--FKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            |...:.:|..:         |:|  |:||....:|:||:|||||||||||||||:|||||:||||
Mouse   131 LSGSSGEAPKD---------NEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHC 186

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM-RDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |:|||| ||||||||||||.||||:||..:::||.|: :.|.|.:|    ..|||:||:||:|.:
Mouse   187 RDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEV----GSQRFSVNMPHKFGI 247

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:||::|||||:.|.||||:||:.|||..||::.:.:|::|:.||::|||
Mouse   248 HNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDK 312

  Fly   322 --QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRS-------C-------------ALSVDS 364
              ...:|.|.| ..|.|....||     ..:|.:..||       |             |||.|:
Mouse   313 ITNSGQRRKKL-AAGAESPQPAS-----GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDN 371

  Fly   365 LATS--TTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLL---DFNFIKVLGKGSFGKVML 424
            ....  .::.|.|..:|.            |..||.|||:...|   :|||||||||||||||||
Mouse   372 RGEEHRASSATDGQLASP------------GENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVML 424

  Fly   425 AEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYV 489
            ||.||.||:||:||||||.|:||||||||||||||||||..||:||.|:.||||.||||||||||
Mouse   425 AELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV 489

  Fly   490 NGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMC 554
            ||||||||||::|:|:..|:.|||||||.||.|||.||||||||||||||||.||||||||||||
Mouse   490 NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC 554

  Fly   555 KEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSI 619
            |||||||:.||||||||||||||||:|.|||.|||||||||||||||||||||||||||:||:||
Mouse   555 KEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESI 619

  Fly   620 MHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDEN---EIRKHPFFAKLDWKELEKRNIKPP 681
            :|||||||||||:|||||||.|:||||.:||||...:|   .|::||||.::||..||::.||||
Mouse   620 LHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPP 684

  Fly   682 FRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPE 735
            |:|::|..||.||||.:||:|:|:||.:...:::.|||:||.|||:    ||.:
Mouse   685 FKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSY----FGED 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pkc98ENP_001287577.1 C2_PKC_epsilon 1..134 CDD:175981 60/132 (45%)
C1_1 177..228 CDD:278556 40/51 (78%)
C1_1 252..304 CDD:278556 34/51 (67%)
STKc_nPKC_epsilon 412..729 CDD:270743 240/319 (75%)
PrkceNP_035234.1 C2_PKC_epsilon 3..135 CDD:175981 60/133 (45%)
C1_1 170..220 CDD:278556 38/49 (78%)
Interaction with actin 223..228 0/4 (0%)
C1_1 243..295 CDD:278556 34/51 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..356 14/51 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 8/39 (21%)
S_TKc 408..668 CDD:214567 211/259 (81%)
STKc_nPKC_epsilon 412..732 CDD:270743 240/323 (74%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 444 1.000 Domainoid score I534
eggNOG 1 0.900 - - E1_KOG0694
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H48343
Inparanoid 1 1.050 873 1.000 Inparanoid score I410
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51944
OrthoDB 1 1.010 - - D222529at2759
OrthoFinder 1 1.000 - - FOG0000117
OrthoInspector 1 1.000 - - otm42557
orthoMCL 1 0.900 - - OOG6_102972
Panther 1 1.100 - - LDO PTHR24356
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R891
SonicParanoid 1 1.000 - - X125
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.870

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