Protein Alignment Pkc98E and Prkce

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_035234.1
• Gene: Prkce / 18754
• MGIID: 97599
• Length: 737
• Species: Mus musculus
• Alignment Length: 769
• Identity: 440/769 - (57%)
• Similarity: 554/769 - (72%)
• Gaps: 71/769 - (9%)

  Fly     1 MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVW 65
            :|.|.|:||:|||..|:||.:..||  ..|......|:|||::::||:|...:..|:.||..|.|
Mouse     3 VFNGLLKIKICEAVSLKPTAWSLRH--AVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAW 65

  Fly    66 NEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE 130
            :::||.||.|...|.|.|||||.:..|||||||.|.||:|:|:.:...:.|::|||:||::|||:
Mouse    66 HDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGKVYVIID 130

  Fly   131 LKNRTDKAKAEAVVEHTVAVNKE--FKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            |...:.:|..:         |:|  |:||....:|:||:|||||||||||||||:|||||:||||
Mouse   131 LSGSSGEAPKD---------NEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHC 186

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM-RDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |:|||| ||||||||||||.||||:||..:::||.|: :.|.|.:|    ..|||:||:||:|.:
Mouse   187 RDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEV----GSQRFSVNMPHKFGI 247

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:||::|||||:.|.||||:||:.|||..||::.:.:|::|:.||::|||
Mouse   248 HNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDK 312

  Fly   322 --QQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRS-------C-------------ALSVDS 364
              ...:|.|.| ..|.|....||     ..:|.:..||       |             |||.|:
Mouse   313 ITNSGQRRKKL-AAGAESPQPAS-----GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDN 371

  Fly   365 LATS--TTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLL---DFNFIKVLGKGSFGKVML 424
            ....  .::.|.|..:|.            |..||.|||:...|   :|||||||||||||||||
Mouse   372 RGEEHRASSATDGQLASP------------GENGEVRPGQAKRLGLDEFNFIKVLGKGSFGKVML 424

  Fly   425 AEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYV 489
            ||.||.||:||:||||||.|:||||||||||||||||||..||:||.|:.||||.||||||||||
Mouse   425 AELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYV 489

  Fly   490 NGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMC 554
            ||||||||||::|:|:..|:.|||||||.||.|||.||||||||||||||||.||||||||||||
Mouse   490 NGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMC 554

  Fly   555 KEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSI 619
            |||||||:.||||||||||||||||:|.|||.|||||||||||||||||||||||||||:||:||
Mouse   555 KEGIMNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESI 619

  Fly   620 MHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDEN---EIRKHPFFAKLDWKELEKRNIKPP 681
            :|||||||||||:|||||||.|:||||.:||||...:|   .|::||||.::||..||::.||||
Mouse   620 LHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPP 684

  Fly   682 FRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKFGPE 735
            |:|::|..||.||||.:||:|:|:||.:...:::.|||:||.|||:    ||.:
Mouse   685 FKPRIKTKRDVNNFDQDFTREEPILTLVDEAIIKQINQEEFKGFSY----FGED 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	60/132 (45%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	47/60 (78%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	35/53 (66%)
		STKc_nPKC_epsilon	412..729	CDD:270743	240/319 (75%)
Prkce	NP_035234.1	C2_PKC_epsilon	3..135	CDD:175981	60/133 (45%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	50/62 (81%)
		Interaction with actin	223..228		0/4 (0%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	35/53 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..356		14/51 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..398		8/39 (21%)
		STKc_nPKC_epsilon	412..732	CDD:270743	240/323 (74%)