DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Prkcd

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001297611.1	Gene:	Prkcd / 18753	MGIID:	97598	Length:	700	Species:	Mus musculus

Alignment Length:	725	Identity:	317/725 - (43%)
Similarity:	437/725 - (60%)	Gaps:	76/725 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DEQLIDPYVSIDVDES-HFDRATT---RPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDDF 94
            :::...|:.::.:.|: ..:|..|   :..|..|.|...|...:.....|.:.:...|..|..:.
Mouse    20 EDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFDAHIYEGRVIQIVLMRAAEDPVSEV 84

  Fly    95 VANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE--LKNRTDKAKAEAVVEHTVAVNKEFKER 157
            .....: ..:..:......:.|::|:||.|:.:.::  |::...|....:            :|.
Mouse    85 TVGVSV-LAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRS------------EEE 136

  Fly   158 AGF--NRRRGAMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCH 219
            |.|  ..||||::: ::|.:..|:|:|||..||||||.|:||:||:.||||:|:.|...:||||.
Mouse   137 AKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCI 201

  Fly   220 LSVVSKCPG----MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGL 280
            ..::.:|.|    .||....|       :|||:::||||.|::|...||||||||||:||:||||
Mouse   202 DKIIGRCTGTATNSRDTIFQK-------ERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGL 259

  Fly   281 QCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLN-------QQGGEDN 338
            :||.||||||.:|::.|||.||||.|.:||.|:.:       ..|.|:.|:       .||.|..
Mouse   260 KCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV-------TQRSSRKLDTTESVGIYQGFEKK 317

  Fly   339 YGASLGADGDGAPGQ------SFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGE 397
            ...| |:|..|..|.      ||.|.|...||             |.:|.:....|....|:|
Mouse   318 PEVS-GSDILGEAGSHISLKLSFPSRAKEKDS-------------SETCDNNGTYGKIWEGST-- 366

  Fly   398 TRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILAL 462
                :|:|.:|.|.|||||||||||:|||.||.|:.:|||.||||.::.||||:|||.|||:|||
Mouse   367 ----RCTLENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLAL 427

  Fly   463 AANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHG 527
            |...||||.|...|||.|.||||||::|||||||.||...|||..||.|||||:...|||||:.|
Mouse   428 AWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKG 492

  Fly   528 VIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWA 592
            :|||||||||::||::||.|:||||||||.|......:||||||||||||||:..:|..|||||:
Mouse   493 IIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWS 557

  Fly   593 LGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDEN 657
            .|||:|||:.||.||..|:|||||:||..|...||.|:::|:..|::....::|::|||.||:
Mouse   558 FGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGN-- 620

  Fly   658 EIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEF 722
             ||.||||..::|..||||.::|||:||:|:|.|.:|||.||..|.|.|:.....::..::|:.|
Mouse   621 -IRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAF 684

  Fly   723 AGFSFVNPKF 732
            .|||||||||
Mouse   685 HGFSFVNPKF 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	17/105 (16%)
		C1_1	177..228	CDD:278556	27/50 (54%)
		C1_1	252..304	CDD:278556	35/51 (69%)
		STKc_nPKC_epsilon	412..729	CDD:270743	184/316 (58%)
Prkcd	NP_001297611.1	C1_1	159..208	CDD:365894	26/48 (54%)
		C1_1	231..281	CDD:365894	33/49 (67%)
		PKc_like	377..692	CDD:389743	185/317 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7921
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850