Protein Alignment Pkc98E and Prkacb

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001157672.1
• Gene: Prkacb / 18749
• MGIID: 97594
• Length: 398
• Species: Mus musculus
• Alignment Length: 346
• Identity: 130/346 - (37%)
• Similarity: 198/346 - (57%)
• Gaps: 8/346 - (2%)

  Fly   359 ALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVM 423
            ||..|.|..|  ..|:.::.|....||......:.......|....|.||...|.||.||||:||
Mouse    44 ALEDDGLRAS--EHTASWDKSMKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVM 106

  Fly   424 LAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEY 488
            |.:.|.|::.||:|:|.|..:::...::.|:.|||||. |...|||..|...|:....|:.||||
Mouse   107 LVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQ-AVEFPFLVRLEYSFKDNSNLYMVMEY 170

  Fly   489 VNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGM 553
            |.||::...:::..||....|.||||::.|..::||:..:||||||.:|:|:|.:|:.::.|||.
Mouse   171 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGF 235

  Fly   554 CKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDS 618
            .|.  :.|. |.|.||||:|:||||:..:.|..:|||||||||:|||.||.|||.||...::::.
Mouse   236 AKR--VKGR-TWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 297

  Fly   619 IMHDDVLYPVWLSREAVSILKGFLTKNPEQRLG-CTGDENEIRKHPFFAKLDWKELEKRNIKPPF 682
            |:...|.:|...|.:...:|:..|..:..:|.| .....::|:.|.:||..||..:.:|.::.||
Mouse   298 IVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPF 362

  Fly   683 RPKMKNPRDANNFDAEFTKED 703
            .||.:...|.:||| ::.:|:
Mouse   363 IPKFRGSGDTSNFD-DYEEEE 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388
		STKc_nPKC_epsilon	412..729	CDD:270743	117/293 (40%)
Prkacb	NP_001157672.1	STKc_PKA	89..378	CDD:271111	118/293 (40%)