Protein Alignment Pkc98E and pkn-1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001360642.1
• Gene: pkn-1 / 181244
• WormBaseID: WBGene00009793
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 745
• Identity: 224/745 - (30%)
• Similarity: 344/745 - (46%)
• Gaps: 140/745 - (18%)

  Fly     4 GKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWNEQ 68
            |.:.:...:|||       |:.....|..:.|::   :..:.:| :.|..||...|..|..|:::
 Worm   505 GFISVYGMDASG-------KKKKSARGPNSSEEV---FCVLRID-NRFIGATELRKIVDRNWDQK 558

  Fly    69 FVHDVTNVSNINLTVFHDAALPPDD-----FVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVI 128
            |..|:.....:.:.:|:.     ||     |.|   :...:|:::.:.| .:.|.:||||.|.|.
 Worm   559 FDVDLDRSRELQIELFYH-----DDRSMCGFAA---VKLSNLIETSSKV-GIIVPVEPQGNIFVQ 614

  Fly   129 IELKN----RTDKAKAEAVVEHTVAVNKEFKERAG---FNRRRGAMRRRVHQVNGHKFMA--TFL 184
            .:..|    |..|.:.:..:......|...:::.|   |:|   .::.|.::.: .||.|  .|.
 Worm   615 FKYMNPVVSRKPKLERQRRLFRVKESNDGARQKLGVFAFSR---LIKNRGNEPS-EKFAAFTGFT 675

  Fly   185 RQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVN 249
            ..|:..|.                      |:          ||.....|:....:.:
 Worm   676 PMPSSSSQ----------------------HQ----------PGTSSSGPSTSSSIAS------- 701

  Fly   250 LPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSS 314
                         |......:.|:..:...|.......:..||..:..|....:.....|..|::
 Worm   702 -------------TPTPSTSNSLFDKVSNHLPSFNPRKSAKKREAREAAAVAPMTAAVAAVNLNA 753

  Fly   315 LGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSS 379
            ...|...|...:.:.|    ..|.:...........|..:.|    .:|..|:
 Worm   754 PSTSNSMQPSTQERNL----VVDEFPTDRSGPSQAPPVPAVR----HIDFFAS------------ 798

  Fly   380 SCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAI 444
                     |.|...|.|         .|..|.|||:|.||||:|::...|...||:|||||..|
 Worm   799 ---------SDGAPLTVE---------QFRLISVLGRGHFGKVILSQHNPTSNYYALKVLKKGDI 845

  Fly   445 IQDDDVDCTMTEKRILALA--ANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEAS 507
            :..|:|:..|.||||..::  |.||||..|:.||||.:.:||.|||..|||||..|.. ..|:..
 Worm   846 LGRDEVESLMVEKRIFEVSSRARHPFLVNLNGCFQTNEHVFFCMEYSMGGDLMRHIHD-DVFDEV 909

  Fly   508 RAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPD 572
            |..||||.|.|.|.|||.|.:||||:||||:|||:||:.|:||||:|||.:.....|:||||||:
 Worm   910 RGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLCKENMGPFDKTSTFCGTPE 974

  Fly   573 YIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSI 637
            ::|||:|.:..|..::|||.||||::||:.|:|||..|:|:|:||||:.:||.||.:||.|:::|
 Worm   975 FLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEEIFDSIISEDVRYPRYLSVESIAI 1039

  Fly   638 LKGFLTKNPEQRLGC-TGDENEIRKHPFFAKL--DWKELEKRNIKPPFRPKMKNPRDANNFDAEF 699
            ::..|.|.||:|||. ..|..:|:...||..:  :|.:|..|.|:|||:|:::||.|.:|||.||
 Worm  1040 MRRLLRKVPEKRLGYGERDAEDIKIQRFFRHISWEWDKLLNREIRPPFQPQIRNPEDVSNFDLEF 1104

  Fly   700 TKEDPVLT------PIGNEVVRCINQDEFA 723
            |:|....:      ||.....|..|..:|:
 Worm  1105 TQEKARFSAASSTRPITEADQRLFNNFDFS 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	31/138 (22%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	9/60 (15%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	6/53 (11%)
		STKc_nPKC_epsilon	412..729	CDD:270743	154/323 (48%)
pkn-1	NP_001360642.1	HR1_PKN_1	188..253	CDD:212012
		HR1_PKN_2	273..339	CDD:212013
		HR1	344..410	CDD:469609
		C2	527..>589	CDD:472691	15/73 (21%)
		STKc_PKN	809..1134	CDD:270741	155/325 (48%)