DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and pkc-2

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001359883.1	Gene:	pkc-2 / 181166	WormBaseID:	WBGene00004033	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	308/699 - (44%)
Similarity:	406/699 - (58%)	Gaps:	128/699 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 AEAVVEHTVAVNK---EFKERAGFNR--RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIW 198
            ::.::|..:|:.|   .|.:|.....  ||||:|:: ||::..|||:|.|.:||||||||::|:|
Worm    67 SDPMLESNLALRKLSEAFAQRIEGKAFVRRGALRQKNVHEIKSHKFIARFFKQPTFCSHCKDFLW 131

  Fly   199 GIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLP---HRFVVHSYK 260
            ||.|||:|||||||||||:||..|...|||             |.:..:.:.|   |::.|.:|.
Worm   132 GITKQGFQCQVCTLVVHKRCHEFVNFACPG-------------ADKGVDTDDPRQQHKWKVQTYS 183

  Fly   261 RFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGI-NTKQMA--------------- 309
            ..||||||||||||::.||::|::|..|||.||.|||.|.||. ||::..
Worm   184 SPTFCDHCGSLLYGILHQGMKCQSCDTNVHHRCVKNVPNMCGTDNTEKRGRLRIEAHIENDQLTI 248

  Fly   310 EILSSLGISP-----------------------DKQQPRRSK-YLNQQGGEDNYGASLGADGDGA 350
            :||.:..:.|                       .||:.:..: .||.|..| .:...|      .
Worm   249 KILEAKNLIPMDPNGLSDPYVKCKLIPEDSGCKSKQKTKTLRATLNPQWNE-TFTYKL------L 306

  Fly   351 PGQSFRSCALSV---DSLATSTTTMTSGYNSSSCMSLAVTG--------SG---GVGATGE---- 397
            ||...|..::.|   |..:.:....:..:..|..|..|.:|        .|   .:..|.|
Worm   307 PGDKDRRLSIEVWDWDRTSRNDFMGSLSFGISELMKEAASGWYKLLSAEEGEFYNINITPEYDED 371

  Fly   398 -------------TRPGKCS------------------------LLDFNFIKVLGKGSFGKVMLA 425
                         ||....|                        ..||||:.||||||||||:|.
Worm   372 MEKVRKKMNENFITRDNSSSKPKDPAAPRASTLPLGSSNHNVIKASDFNFLTVLGKGSFGKVLLG 436

  Fly   426 EKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVN 490
            |:|.|.|::||||||||.|||||||:|||||||:|||.....||.||||||||.|||:||||:||
Worm   437 EQKTTKELFAIKVLKKDVIIQDDDVECTMTEKRVLALPEKPSFLVALHSCFQTMDRLYFVMEFVN 501

  Fly   491 GGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCK 555
            |||||:|||:..:|:...|.|||||:.:.|.|||:.|:|||||||||::|:::||.|:.||||||
Worm   502 GGDLMYQIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKITDFGMCK 566

  Fly   556 EGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIM 620
            |.|.....|.|||||||||||||:..|.||.||||||.|||::||:||||||:.::|||||.:|.
Worm   567 ENIFGDATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLFEMLAGQPPFDGEDEDELFTAIT 631

  Fly   621 HDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDE----NEIRKHPFFAKLDWKELEKRNIKPP 681
            ..:|.||..||:||||:.|..|.|||.:|||||||:    .:|::||||.::||.::|.|.|:||
Worm   632 EHNVSYPKSLSKEAVSLCKALLIKNPSKRLGCTGDDESASRDIKEHPFFRRIDWFKIETRQIQPP 696

  Fly   682 FRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            |:||:|..|...|||..|.|....:||...||:..:..|||:.||||||
Worm   697 FKPKLKTDRSTENFDHSFLKLPTKMTPPDWEVLENLKGDEFSNFSFVNP 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	35/50 (70%)
		C1_1	252..304	CDD:278556	30/52 (58%)
		STKc_nPKC_epsilon	412..729	CDD:270743	193/320 (60%)
pkc-2	NP_001359883.1	C1_1	110..160	CDD:365894	34/49 (69%)
		C1_1	175..225	CDD:365894	28/49 (57%)
		C2_PKC_alpha_gamma	232..362	CDD:175992	20/136 (15%)
		STKc_cPKC	422..744	CDD:270739	193/321 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51944
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950