DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and tpa-1

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001379590.1	Gene:	tpa-1 / 176825	WormBaseID:	WBGene00006599	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	748	Identity:	308/748 - (41%)
Similarity:	426/748 - (56%)	Gaps:	97/748 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVD-ESHFDRATTRPKTFDPVWNEQFVHDVT 74
            |.|:.|:|.                  ::....|:|: ||   |...:.||..|.|.:.:...|.
Worm    26 CSATDLQPA------------------VNVKEKIEVNGES---RLVQKKKTLYPEWEKCWDTAVA 69

  Fly    75 N------VSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKI-----HVI 128
            .      |...|.|...:|.:..:|.::.|         ...|:..:|:|.:|.|:|     |
Worm    70 EGRILQIVLMFNQTPVVEATMRLEDIISKC---------KSDAITHIWINTKPNGRILAQTRH-- 123

  Fly   129 IELKNRTDKAKAEAVVEHTV--AVNKEFKERAGFNRRRGAMRR-RVHQVNGHKFMATFLRQPTFC 190
              |||..|.       :|.|  .:........|..|||||::. |||::.||:|:|||.|||.||
Worm   124 --LKNAPDD-------DHPVEDIMTSRSNSGPGIQRRRGAIKHARVHEIRGHQFVATFFRQPHFC 179

  Fly   191 SHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFV 255
            |.|.:|:||:.|||||||:|:..||||||..|:.:|||......   |.:...:||.|::||||.
Worm   180 SLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTK---ETMALKERFKVDIPHRFK 241

  Fly   256 VHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSL--GIS 318
            .:::|..||||||||:||||.||||:||.|.:..|.:|::.::|.||:|.||::|:...:  |..
Worm   242 TYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCGVNQKQLSEMYHEIKRGTH 306

  Fly   319 PDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQ---SFRSCALSVDSLATSTTTMTSGYNSSS 380
            .....|.....|:..|.......||       |.:   .|:|...||:....:...|.:.:
Worm   307 ATASCPPNIANLHLNGETSKNNGSL-------PNKLKNLFKSHQYSVEEQKETDEYMDNIW---- 360

  Fly   381 CMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII 445
                     ||    |:....|.:|..||.:|||||||||||||.|.||.:|.||:|.||||.|:
Worm   361 ---------GG----GDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVIL 412

  Fly   446 QDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAA 510
            :|||.:||..|:|:|.||:..|||..|...|||.:.|||||||:||||||..||:.::|:.:|..
Worm   413 EDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTR 477

  Fly   511 FYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGI--MNGMLTTTFCGTPDY 573
            |||.|:.:|||||||:.:|||||||||:|||.:||.|||||||.|..:  .||| .:||||||||
Worm   478 FYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGM-ASTFCGTPDY 541

  Fly   574 IAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSIL 638
            |:|||:|.|.|..:||:|:.|||||||:.||.||..:.||||||||:::...:|..:|:||...|
Worm   542 ISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCL 606

  Fly   639 KGFLTKNPEQRLG---CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFT 700
            .....:||..|||   |  .:..||:|.||..:|||..|.|.:.|||:|.:|:..||:|||.:||
Worm   607 SALFDRNPNTRLGMPEC--PDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFT 669

  Fly   701 KEDPVLTPIGNE-VVRCINQDEFAGFSFVNPKF 732
            .|...|||:.:: ::..|:.:.|..||:.||.|
Worm   670 NEKAALTPVHDKNLLASIDPEAFLNFSYTNPHF 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	29/134 (22%)
		C1_1	177..228	CDD:278556	31/50 (62%)
		C1_1	252..304	CDD:278556	28/51 (55%)
		STKc_nPKC_epsilon	412..729	CDD:270743	173/322 (54%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384	37/59 (63%)
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	26/48 (54%)
		STKc_nPKC_theta_like	379..700	CDD:270744	173/323 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950