Protein Alignment Pkc98E and tpa-1

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_001379590.1
• Gene: tpa-1 / 176825
• WormBaseID: WBGene00006599
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 748
• Identity: 308/748 - (41%)
• Similarity: 426/748 - (56%)
• Gaps: 97/748 - (12%)

  Fly    11 CEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVD-ESHFDRATTRPKTFDPVWNEQFVHDVT 74
            |.|:.|:|.                  ::....|:|: ||   |...:.||..|.|.:.:...|.
 Worm    26 CSATDLQPA------------------VNVKEKIEVNGES---RLVQKKKTLYPEWEKCWDTAVA 69

  Fly    75 N------VSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKI-----HVI 128
            .      |...|.|...:|.:..:|.::.|         ...|:..:|:|.:|.|:|     |
 Worm    70 EGRILQIVLMFNQTPVVEATMRLEDIISKC---------KSDAITHIWINTKPNGRILAQTRH-- 123

  Fly   129 IELKNRTDKAKAEAVVEHTV--AVNKEFKERAGFNRRRGAMRR-RVHQVNGHKFMATFLRQPTFC 190
              |||..|.       :|.|  .:........|..|||||::. |||::.||:|:|||.|||.||
 Worm   124 --LKNAPDD-------DHPVEDIMTSRSNSGPGIQRRRGAIKHARVHEIRGHQFVATFFRQPHFC 179

  Fly   191 SHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFV 255
            |.|.:|:||:.|||||||:|:..||||||..|:.:|||......   |.:...:||.|::||||.
 Worm   180 SLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTK---ETMALKERFKVDIPHRFK 241

  Fly   256 VHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSL--GIS 318
            .:::|..||||||||:||||.||||:||.|.:..|.:|::.::|.||:|.||::|:...:  |..
 Worm   242 TYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCGVNQKQLSEMYHEIKRGTH 306

  Fly   319 PDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQ---SFRSCALSVDSLATSTTTMTSGYNSSS 380
            .....|.....|:..|.......||       |.:   .|:|...||:....:...|.:.:
 Worm   307 ATASCPPNIANLHLNGETSKNNGSL-------PNKLKNLFKSHQYSVEEQKETDEYMDNIW---- 360

  Fly   381 CMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII 445
                     ||    |:....|.:|..||.:|||||||||||||.|.||.:|.||:|.||||.|:
 Worm   361 ---------GG----GDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVIL 412

  Fly   446 QDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAA 510
            :|||.:||..|:|:|.||:..|||..|...|||.:.|||||||:||||||..||:.::|:.:|..
 Worm   413 EDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTR 477

  Fly   511 FYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGI--MNGMLTTTFCGTPDY 573
            |||.|:.:|||||||:.:|||||||||:|||.:||.|||||||.|..:  .||| .:||||||||
 Worm   478 FYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGM-ASTFCGTPDY 541

  Fly   574 IAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSIL 638
            |:|||:|.|.|..:||:|:.|||||||:.||.||..:.||||||||:::...:|..:|:||...|
 Worm   542 ISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCL 606

  Fly   639 KGFLTKNPEQRLG---CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFT 700
            .....:||..|||   |  .:..||:|.||..:|||..|.|.:.|||:|.:|:..||:|||.:||
 Worm   607 SALFDRNPNTRLGMPEC--PDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFT 669

  Fly   701 KEDPVLTPIGNE-VVRCINQDEFAGFSFVNPKF 732
            .|...|||:.:: ::..|:.:.|..||:.||.|
 Worm   670 NEKAALTPVHDKNLLASIDPEAFLNFSYTNPHF 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	29/134 (22%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	36/58 (62%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	29/53 (55%)
		STKc_nPKC_epsilon	412..729	CDD:270743	173/322 (54%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384	37/59 (63%)
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	26/48 (54%)
		STKc_nPKC_theta_like	379..700	CDD:270744	173/323 (54%)