DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and pkc-3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_495011.1	Gene:	pkc-3 / 173914	WormBaseID:	WBGene00004034	Length:	597	Species:	Caenorhabditis elegans

Alignment Length:	648	Identity:	247/648 - (38%)
Similarity:	336/648 - (51%)	Gaps:	141/648 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 ISFEDLMQSETAVQDLWVNLEPQGKIHVII---ELKNRTDKAKAEAVVEHTVAVNKEFKERAGFN 161
            ||.:..|:.:.||:.|..:.|.:..|||.:   ||.....:.:.:.|.
Worm    65 ISIDSQMELDEAVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVY----------------- 112

  Fly   162 RRRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSK 225
             ||||.| ::::..|||:|.|..|.:...|..|.::|||||:||::|..|.|.||||||..|.:
Worm   113 -RRGARRWKKIYLYNGHRFQAKRLNRRIQCFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRT- 175

  Fly   226 CPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVH 290
                                                     |||        |.||
Worm   176 -----------------------------------------HCG--------QALQ--------- 182

  Fly   291 KRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSF 355
                       |.|...||....||                 :|...|..:|....|.|
Worm   183 -----------GPNIIPMAPASGSL-----------------KGARSNTSSSTTRSGGG------ 213

  Fly   356 RSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFG 420
                  :|:.|.....:.|..::|...|.|:.|:|       :.....||.||..:.|:|:||:.
Worm   214 ------IDNGAFHEHEIESPGSTSHDASRAMNGNG-------SSKWAVSLNDFRLLTVIGRGSYA 265

  Fly   421 KVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFV 485
            ||:.||...|.:|||||::||:...:|:|:|...|||.:...|:|:|||..|||||||..|||||
Worm   266 KVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFV 330

  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550
            :|:|.||||||.:|:.|:.....|.||:.|:.|||.|||:.|:|||||||||:|:|.|||.||.|
Worm   331 IEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTD 395

  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF-------- 607
            :|||||.|.:|.||:||||||:|||||||:..|||.|||||||||||:|||||:.||
Worm   396 YGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNS 460

  Fly   608 EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENE----IRKHPFF-AK 667
            |.:.||.||..|:...:..|..||..|..||||||.|:|.:||||..|.||    :::|.|| ..
Worm   461 EENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGF 525

  Fly   668 LDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            :||:.||::.:.||:.|.:::.||..:||.:||.|.|.|:|...:|:..|:|.||.||.:|||
Worm   526 IDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNP 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	12/36 (33%)
		C1_1	177..228	CDD:278556	23/50 (46%)
		C1_1	252..304	CDD:278556	7/51 (14%)
		STKc_nPKC_epsilon	412..729	CDD:270743	172/329 (52%)
pkc-3	NP_495011.1	PB1_aPKC	13..95	CDD:99725	10/29 (34%)
		C1_1	128..178	CDD:278556	24/91 (26%)
		S_TKc	253..522	CDD:214567	147/268 (55%)
		PKc_like	257..586	CDD:304357	172/328 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910