Protein Alignment Pkc98E and pkc-3

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_495011.1
• Gene: pkc-3 / 173914
• WormBaseID: WBGene00004034
• Length: 597
• Species: Caenorhabditis elegans
• Alignment Length: 648
• Identity: 247/648 - (38%)
• Similarity: 336/648 - (51%)
• Gaps: 141/648 - (21%)

  Fly   100 ISFEDLMQSETAVQDLWVNLEPQGKIHVII---ELKNRTDKAKAEAVVEHTVAVNKEFKERAGFN 161
            ||.:..|:.:.||:.|..:.|.:..|||.:   ||.....:.:.:.|.
 Worm    65 ISIDSQMELDEAVRCLNSSQEAELNIHVFVGKPELPGLPCQGEDKTVY----------------- 112

  Fly   162 RRRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSK 225
             ||||.| ::::..|||:|.|..|.:...|..|.::|||||:||::|..|.|.||||||..|.:
 Worm   113 -RRGARRWKKIYLYNGHRFQAKRLNRRIQCFICHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRT- 175

  Fly   226 CPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVH 290
                                                     |||        |.||
 Worm   176 -----------------------------------------HCG--------QALQ--------- 182

  Fly   291 KRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSF 355
                       |.|...||....||                 :|...|..:|....|.|
 Worm   183 -----------GPNIIPMAPASGSL-----------------KGARSNTSSSTTRSGGG------ 213

  Fly   356 RSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFG 420
                  :|:.|.....:.|..::|...|.|:.|:|       :.....||.||..:.|:|:||:.
 Worm   214 ------IDNGAFHEHEIESPGSTSHDASRAMNGNG-------SSKWAVSLNDFRLLTVIGRGSYA 265

  Fly   421 KVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFV 485
            ||:.||...|.:|||||::||:...:|:|:|...|||.:...|:|:|||..|||||||..|||||
 Worm   266 KVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESRLFFV 330

  Fly   486 MEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLAD 550
            :|:|.||||||.:|:.|:.....|.||:.|:.|||.|||:.|:|||||||||:|:|.|||.||.|
 Worm   331 IEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHIKLTD 395

  Fly   551 FGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF-------- 607
            :|||||.|.:|.||:||||||:|||||||:..|||.|||||||||||:|||||:.||
 Worm   396 YGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVGMQNS 460

  Fly   608 EADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENE----IRKHPFF-AK 667
            |.:.||.||..|:...:..|..||..|..||||||.|:|.:||||..|.||    :::|.|| ..
 Worm   461 EENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQFFRGF 525

  Fly   668 LDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNP 730
            :||:.||::.:.||:.|.:::.||..:||.:||.|.|.|:|...:|:..|:|.||.||.:|||
 Worm   526 IDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEYVNP 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	12/36 (33%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	25/58 (43%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	7/53 (13%)
		STKc_nPKC_epsilon	412..729	CDD:270743	172/329 (52%)
pkc-3	NP_495011.1	PB1_aPKC	13..95	CDD:99725	10/29 (34%)
		C1_aPKC	126..180	CDD:410344	28/103 (27%)
		STKc_aPKC	257..586	CDD:270740	172/328 (52%)