DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and Sgk3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001032848.1	Gene:	Sgk3 / 170755	MGIID:	2182368	Length:	496	Species:	Mus musculus

Alignment Length:	361	Identity:	156/361 - (43%)
Similarity:	221/361 - (61%)	Gaps:	17/361 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 YNSSSCMSLAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLK 440
            :::|..::|..||:.....|           ||:|:||:||||||||:||::|...:.||:|||:
Mouse   141 HSTSRNINLGPTGNPHAKPT-----------DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQ 194

  Fly   441 KDAIIQDDDVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFE 505
            |..::...:....|.|:.:|.....||||..||..|||.::|:||:::||||:|.|.:|:.|.|.
Mouse   195 KKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFP 259

  Fly   506 ASRAAFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGT 570
            ..||.|||||:..||.:||:..::|||||.:|||||..||..|.|||:|||||.....|||||||
Mouse   260 EPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGT 324

  Fly   571 PDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAV 635
            |:|:|||::::|.|..:||||.||.::|||:.|.|||...:..|::|:|:|..:.....:|..|.
Mouse   325 PEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAW 389

  Fly   636 SILKGFLTKNPEQRLGCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFT 700
            |||:..|.||.:.|||...|..||:.||||..|.|.:|.::.|.|||.|.:..|.|..||||.||
Mouse   390 SILEELLEKNRQNRLGAKEDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFDAVFT 454

  Fly   701 KEDPVLTPIGNEVVRCIN------QDEFAGFSFVNP 730
            :|....:...:.....:|      .|.|.|||:..|
Mouse   455 EETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	147/322 (46%)
Sgk3	NP_001032848.1	PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		4/15 (27%)
		S_TKc	162..419	CDD:214567	124/256 (48%)
		STKc_SGK3	165..490	CDD:270755	147/324 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910