Protein Alignment Pkc98E and Prkcd

DIOPT Version :10

• Sequence 1: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Sequence 2: NP_579841.2
• Gene: Prkcd / 170538
• RGDID: 67383
• Length: 673
• Species: Rattus norvegicus
• Alignment Length: 715
• Identity: 302/715 - (42%)
• Similarity: 420/715 - (58%)
• Gaps: 80/715 - (11%)

  Fly    33 ADEQLIDPYVSIDVDES-HFDRATT---RPKTFDPVWNEQFVHDVTNVSNINLTVFHDAALPPDD 93
            |::....|:.::.:.|: ..||..|   :..|..|.|...|...:.....|.:.:...|..|..:
  Rat    19 AEDDASQPFCAVKMKEALTTDRGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEDPMSE 83

  Fly    94 FVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE--LKNRTDKAKAEAVVEHTVAVNKEFKE 156
            ......: ..:..:......:.|::|:||.|:.:.::  |::...|....:            :|
  Rat    84 VTVGVSV-LAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRS------------EE 135

  Fly   157 RAGF--NRRRGAMRR-RVHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKC 218
            .|.|  ..||||::: ::|.:..|:|:|||..||||||.|:||:||:.||||:|:.|...:||||
  Rat   136 EAMFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKC 200

  Fly   219 HLSVVSKCPG----MRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQG 279
            ...::.:|.|    .||....|       :|||:::||||.|::|...||||||||||:||:|||
  Rat   201 IDKIIGRCTGTATNSRDTIFQK-------ERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQG 258

  Fly   280 LQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASLG 344
            |:||.||||||.:|::.|||.||||.|.:||.|:.:    .::..|:.:.....|....:.....
  Rat   259 LKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQV----TQKASRKPETPETVGIYQGFEKKTA 319

  Fly   345 ADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETRPG--KCSLLD 407
            ..|:..|..:                                      |..|:...|  :|.|.:
  Rat   320 VSGNDIPDNN--------------------------------------GTYGKIWEGSNRCRLEN 346

  Fly   408 FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTAL 472
            |.|.|||||||||||:|||.||.:..:|||.||||.::.||||:|||.|||:||||..:||||.|
  Rat   347 FTFQKVLGKGSFGKVLLAELKGKERYFAIKYLKKDVVLIDDDVECTMVEKRVLALAWENPFLTHL 411

  Fly   473 HSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDN 537
            ...|||.|.||||||::|||||||.||...|||..||.|||||:...|||||..|:|||||||||
  Rat   412 ICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHGKGIIYRDLKLDN 476

  Fly   538 ILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMA 602
            ::||::||.|:||||||||.|......:||||||||||||||:..:|..|||||:.|||:|||:.
  Rat   477 VMLDKDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLI 541

  Fly   603 GQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFAK 667
            ||.||..|:|||||:||..|...||.|:::|:..|::....::|.:|||.||:   ||.||||..
  Rat   542 GQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPAKRLGVTGN---IRLHPFFKT 603

  Fly   668 LDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVNPKF 732
            ::|..||||.::|||:||:|:|.|.:|||.||..|.|.|:.....::..::|..|.||||||||:
  Rat   604 INWNLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQTAFKGFSFVNPKY 668

  Fly   733  732
              Rat   669  668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981	19/106 (18%)
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	29/62 (47%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	36/53 (68%)
		STKc_nPKC_epsilon	412..729	CDD:270743	183/316 (58%)
Prkcd	NP_579841.2	C1_nPKC_theta-like_rpt1	152..212	CDD:410384	29/59 (49%)
		C1_nPKC_theta-like_rpt2	231..280	CDD:410387	33/48 (69%)
		Protein Kinases, catalytic domain	351..666	CDD:473864	184/317 (58%)