DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and SGK2

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001186193.1	Gene:	SGK2 / 10110	HGNCID:	13900	Length:	367	Species:	Homo sapiens

Alignment Length:	347	Identity:	146/347 - (42%)
Similarity:	215/347 - (61%)	Gaps:	22/347 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 GVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMT 455
            |..|....:|     .||:|:||:|||::|||:||::|.....||:|||:|.:|::..:....|.
Human    23 GPSANPNAQP-----TDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMA 82

  Fly   456 EKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLAL 520
            |:.:|.....||||..|...||||::|:||::|||||:|.|.:|:.|||...||.||||||..|:
Human    83 ERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAI 147

  Fly   521 QFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYG 585
            .:||:..:||||||.:|||||.:||..|.|||:||||:.....|:||||||:|:|||:|:::.|.
Human   148 GYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYD 212

  Fly   586 ASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRL 650
            .:||||.||.::|||:.|.|||.:.:..:::::|:|..:..|...:..|..:|:..|.|:..|||
Human   213 RAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL 277

  Fly   651 GCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKE----------DPV 705
            |...|..||:.|.||:.::|.:|..:.:.|||.|.:..|.|..:||.|||:|          |.|
Human   278 GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTV 342

  Fly   706 LTPIGNEVVRCINQDEFAGFSF 727
            .:..|       ....|.|||:
Human   343 ASSSG-------ASSAFLGFSY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	140/326 (43%)
SGK2	NP_001186193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		1/2 (50%)
		STKc_SGK2	39..359	CDD:270754	140/326 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910