DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and rskrb

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_003200943.1	Gene:	rskrb / 100537227	ZFINID:	ZDB-GENE-120215-252	Length:	445	Species:	Danio rerio

Alignment Length:	323	Identity:	95/323 - (29%)
Similarity:	153/323 - (47%)	Gaps:	26/323 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTAL 472
            |..:..:.|||||.::..:.|...:.||:||:.|..|::...:: ...|:.|:.....|||:..|
Zfish   102 FQVLGYIAKGSFGPILKVKDKSKQKTYAVKVIPKSEILRLGVLE-QSKEEVIVQRQVRHPFVHDL 165

  Fly   473 HSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDN 537
            ..|:||...::.:.:|.:.|||........:|.......:|||:..||.|||...:|:||:|::|
Zfish   166 QDCWQTQRHIYIMCDYCSTGDLYTYWVMIGQFGEDVVKVFAAELGSALGFLHDCAIIHRDVKMEN 230

  Fly   538 ILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMA 602
            :||..:||.:|||||:.:. :..|....|.|||..|:|||:|....|..:.|||:||:|::.:..
Zfish   231 VLLTDQGHLRLADFGLSRR-LERGGRAFTICGTIQYMAPEVLSGGPYNHASDWWSLGILLFALAT 294

  Fly   603 GQPPFEADNEDELF----DSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRL------------- 650
            |:.|...:.:..|.    .|..:|   .|...|.....:|...|.|.|.:||
Zfish   295 GKFPVPPEPDHCLMLRRVRSFPYD---MPKTFSPSFALLLTELLCKTPARRLRTLERFKRQTFFH 356

  Fly   651 GCTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEV 713
            |...|.:.::|.|....|   ||:.|..:|....:........|||.:|....| .||...::
Zfish   357 GTPFDSHLLQKTPMELIL---ELKNRPDRPAKARRGLTLESFPNFDCDFLLSSP-CTPAAQDL 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	94/319 (29%)
rskrb	XP_003200943.1	S_TKc	102..355	CDD:214567	79/257 (31%)
rskrb	XP_003200943.1	STKc_AGC	108..355	CDD:270693	78/251 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900