DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and C8orf44-SGK3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	NP_001191102.1	Gene:	C8orf44-SGK3 / 100533105	HGNCID:	48354	Length:	496	Species:	Homo sapiens

Alignment Length:	330	Identity:	149/330 - (45%)
Similarity:	209/330 - (63%)	Gaps:	6/330 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 DFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTA 471
            ||:|:||:||||||||:||::|...:.||:|||:|..::...:....|.|:.:|.....||||..
Human   161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVG 225

  Fly   472 LHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLD 536
            ||..|||.::|:||:::||||:|.|.:|:.|.|...||.|||||:..||.:||:..::|||||.:
Human   226 LHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPE 290

  Fly   537 NILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMM 601
            |||||..||..|.|||:|||||.....||||||||:|:|||::::|.|..:||||.||.::|||:
Human   291 NILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEML 355

  Fly   602 AGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEIRKHPFFA 666
            .|.|||...:..|::|:|:|..:.....:|..|.|||:..|.|:.:.|||...|..||:.||||.
Human   356 YGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFE 420

  Fly   667 KLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCIN------QDEFAGF 725
            .|.|.:|.::.|.|||.|.:..|.|..|||..||:|....:...:.....:|      .|.|.||
Human   421 SLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGF 485

  Fly   726 SFVNP 730
            |:..|
Human   486 SYAPP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556
		C1_1	252..304	CDD:278556
		STKc_nPKC_epsilon	412..729	CDD:270743	145/322 (45%)
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..156
		STKc_SGK3	165..490	CDD:270755	145/324 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		1/9 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910