DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkc98E and sgk3

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_012820716.1	Gene:	sgk3 / 100491891	XenbaseID:	XB-GENE-492582	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	187/539 - (34%)
Similarity:	277/539 - (51%)	Gaps:	91/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 SKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMN 288
            |.||.:|         :|:   :|....:|      ||||        :|.:|      .:.|.|
Frog     5 SNCPSVR---------IPS---YNEQRQNR------KRFT--------VYKVI------VSMGRN 37

  Fly   289 ---VHKRCQK--NVANTC-----GINTKQMAEILSSLGISPDKQQPRRSKYLNQQGGEDNYGASL 343
               |.:|..:  .:.||.     .:|.|..|:.:......||..|.||:       |.:.:..:|
Frog    38 EWFVFRRYAEFDKLYNTLRKQYPHMNLKIPAKRIFGDNFDPDFIQQRRA-------GLNEFIQNL 95

  Fly   344 GADGD---GAPGQSFRSCALSVDS------LATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETR 399
            ....:   .:..|||    |.:||      .:..........|.|:...:.:..||...|    :
Frog    96 LRHSELCSHSDVQSF----LQLDSPKHQSDPSEDEDERVDQKNGSASRDVNLGPSGNPHA----K 152

  Fly   400 PGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAA 464
            |.     ||.::|::||||||||:|...|.....||:|||:|:.|:...:....|.|:.:|....
Frog   153 PS-----DFEYLKLIGKGSFGKVVLTRGKRDGRYYAVKVLQKNVILNKKEQRHIMAERNVLLKNV 212

  Fly   465 NHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVI 529
            .||||..||..|||.|:||||::::|||:|.|.:|:.|.|...||.|||||:..||.:||:..:|
Frog   213 KHPFLVTLHYSFQTSDKLFFVLDFINGGELFFHLQRERYFAEPRALFYAAEIGSALGYLHSIDII 277

  Fly   530 YRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALG 594
            |||||.:|||||.:||..|.|||:|||||.|...|.||||||:|:|||::.:|.|..:||||.||
Frog   278 YRDLKPENILLDSQGHIVLTDFGLCKEGISNSDTTLTFCGTPEYLAPEVIVKQPYDNTVDWWCLG 342

  Fly   595 VLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCTGDENEI 659
            .::|||:.|.|||...:...::::|:|..:.....:|..|:|||:..|.|:|:.|||...|..:|
Frog   343 SVLYEMLHGLPPFYNRDTATMYENILHKPLTTRPDISLPAISILEELLEKDPKLRLGVNNDFQDI 407

  Fly   660 RKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCIN------ 718
            :.|.|||.::|.:|.::.:.||:.|.:..|.|.:|||.|||:|   :.|..    .|::
Frog   408 KNHAFFASINWADLVEKKMTPPYDPHVNGPDDISNFDKEFTEE---MVPYS----VCVSSDYSIV 465

  Fly   719 -------QDEFAGFSFVNP 730
                   .|.|.|||:..|
Frog   466 NASVEEADDAFVGFSYAPP 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981
		C1_1	177..228	CDD:278556	2/3 (67%)
		C1_1	252..304	CDD:278556	13/61 (21%)
		STKc_nPKC_epsilon	412..729	CDD:270743	143/329 (43%)
sgk3	XP_012820716.1	PX_domain	7..114	CDD:383026	32/149 (21%)
sgk3	XP_012820716.1	STKc_SGK3	159..484	CDD:270755	143/331 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910