DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and prkch

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_002939521.2	Gene:	prkch / 100151731	XenbaseID:	XB-GENE-486685	Length:	691	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	382/740 - (51%)
Similarity:	495/740 - (66%)	Gaps:	79/740 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVWN 66
            |.|.|::|:.||..|:||.:..||:: |.|  ...|:|||::|:|||....:.:.:.:|..|.:|
Frog     7 FNGSLKLKIGEAVELQPTRWSLRHSV-FKK--GSCLLDPYITINVDECRIGQTSIKHRTNKPTYN 68

  Fly    67 EQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQ--SETAVQDLWVNLEPQGKIHVII 129
            |:|...|:..|.:.|.|||:..:..|||||:|.:|||:|::  ..|...:.|::|||:||:.|:|
Frog    69 EEFCVTVSEGSKVELAVFHETPIGYDDFVAHCTLSFEELIKGCGTTDSFEGWMDLEPEGKLFVVI 133

  Fly   130 ELKNRTDKAKAEAVVEHTVAVNKEFKERAGFNRRR-GAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            .|        .....|.|:...:..|.   |.|:| .|||||||||||||||||:|:|||:||||
Frog   134 TL--------IGTFTEGTMRDGRLIKH---FTRKRQRAMRRRVHQVNGHKFMATYLKQPTYCSHC 187

  Fly   194 REFIWGI-GKQGYQCQVCTLVVHKKCHLSVVSKCPGMRDEQPAKVEMVPAGQRFNVNLPHRFVVH 257
            ::||||: |||||||||||.||||:||..:|:.|  ......:|||.....|||.:||||:|..|
Frog   188 KDFIWGVFGKQGYQCQVCTCVVHKRCHQLIVTAC--TCKSTTSKVEKQIFEQRFGINLPHKFRYH 250

  Fly   258 SYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPD-- 320
            :||..||||||||||:||:||||||:.|.|||||||:.|||:.||:|:..:|..|:.:|:.|.
Frog   251 NYKVPTFCDHCGSLLWGLVKQGLQCKICKMNVHKRCEANVAHNCGVNSVDLANALAGMGLHPGNI 315

  Fly   321 --KQQPRRSKYLNQQGGEDNYGASLGADGDGAPGQSFRSCALSVDSLATSTTTMTSGYNSSSCMS 383
              ||                :..|...|.|        |..|..||::.:::....|.:
Frog   316 PFKQ----------------HSVSGSVDSD--------SNHLEEDSISNTSSQYKFGID------ 350

  Fly   384 LAVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDD 448
                                   ||.|::|||||||||||||:.|.:|.:||:||||||.|:|||
Frog   351 -----------------------DFTFLRVLGKGSFGKVMLAKSKESDSLYAVKVLKKDVILQDD 392

  Fly   449 DVDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYA 513
            ||:|||||||||:||.||||||.|..||||.||||||||:||||||||.|||:|||:.:||.||:
Frog   393 DVECTMTEKRILSLACNHPFLTQLFCCFQTLDRLFFVMEFVNGGDLMFHIQKSRRFDEARACFYS 457

  Fly   514 AEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEI 578
            ||:|.||.|||..|||||||||||:|||.||||||||||||||||..|..|:|||||||||||||
Frog   458 AEITSALMFLHDKGVIYRDLKLDNVLLDHEGHCKLADFGMCKEGIREGCTTSTFCGTPDYIAPEI 522

  Fly   579 LKEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLT 643
            |:|.:||..|||||:|||:|||:.|..||||:|||:||::|::|:|:||.|||::||.||:.|:.
Frog   523 LQEMQYGPLVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPGWLSQDAVEILQAFMK 587

  Fly   644 KNPEQRLG--CTGDENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVL 706
            |.|.:|||  ..|.|..|..||||..::|.||.|:.|:|||||::|...|.:|||.||.|||.||
Frog   588 KKPAKRLGSLSLGGEKAILWHPFFKDINWDELNKKTIEPPFRPRIKAREDVSNFDPEFIKEDAVL 652

  Fly   707 TPIGNEVVRCINQDEFAGFSFVNPK 731
            |||...::..|||:||..||:..|:
Frog   653 TPIDESLLPLINQEEFRNFSYTAPE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	52/133 (39%)
		C1_1	177..228	CDD:278556	37/51 (73%)
		C1_1	252..304	CDD:278556	36/51 (71%)
		STKc_nPKC_epsilon	412..729	CDD:270743	212/318 (67%)
prkch	XP_002939521.2	C2_PKC_epsilon	7..139	CDD:175981	52/142 (37%)
		C1_1	171..221	CDD:365894	36/49 (73%)
		C1_1	245..295	CDD:365894	34/49 (69%)
		STKc_nPKC_eta	356..678	CDD:270742	213/322 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6969
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.110