DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkc98E and prkce

DIOPT Version :9

Sequence 1:	NP_001287577.1	Gene:	Pkc98E / 43428	FlyBaseID:	FBgn0003093	Length:	739	Species:	Drosophila melanogaster
Sequence 2:	XP_012818146.1	Gene:	prkce / 100135720	XenbaseID:	XB-GENE-981655	Length:	753	Species:	Xenopus tropicalis

Alignment Length:	786	Identity:	445/786 - (56%)
Similarity:	560/786 - (71%)	Gaps:	89/786 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFTGKLQIKVCEASGLRPTDFQKRHNLTFGKLADEQLIDPYVSIDVDESHFDRATTRPKTFDPVW 65
            :|.|.|:|::|||:.|:||.:..||  ..|......|:|||::::||:|...:.:|:.|:.:|.|
Frog     3 VFNGLLKIRICEATNLKPTAWSLRH--AVGPRPQTFLLDPYIAVNVDDSRIGQTSTKQKSNNPTW 65

  Fly    66 NEQFVHDVTNVSNINLTVFHDAALPPDDFVANCIISFEDLMQSETAVQDLWVNLEPQGKIHVIIE 130
            ::.|..||:|...|.|.||||:.:..|||||||.|.||||:|:.:...:.|::|||:||::|||:
Frog    66 HDDFSTDVSNGKKIELAVFHDSPIGYDDFVANCTIQFEDLLQNGSRHFEDWIDLEPEGKVYVIID 130

  Fly   131 LKNRTDKAKAEAVVEHTVAVNKE--FKERAGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHC 193
            |...:.:|..|         |:|  |:||....:|:||:|||||||||||||||:|||||:||||
Frog   131 LSGSSGEAPKE---------NEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHC 186

  Fly   194 REFIWG-IGKQGYQCQVCTLVVHKKCHLSVVSKCPGM-RDEQPAKVEMVPAGQRFNVNLPHRFVV 256
            |:|||| ||||||||||||.||||:||..:::||.|: :.|.|.:|    ..|||:||:||:|.:
Frog   187 RDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDEV----GSQRFSVNMPHKFGI 247

  Fly   257 HSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHKRCQKNVANTCGINTKQMAEILSSLGISPDK 321
            |:||..||||||||||:||::|||||:.|.||||:||:.|||..||::::.:|::|:.||::|||
Frog   248 HNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCESNVAPNCGVDSRGIAKVLADLGVTPDK 312

  Fly   322 ---QQPRRSKYLN---------------QQ---GG---EDNYGASLGADGDGAP----GQSFRSC 358
               ...||.|..|               ||   ||   ||:...|       ||    .|..:..
Frog   313 ITAAGQRRKKKRNALIFSPMKLIAGAETQQPVPGGPAVEDDRSKS-------APTSPCDQEIKDL 370

  Fly   359 ------ALSVD-------SLATSTTTMTSGYNSSSCMSLAVTGSGGVGATGETR---PGKCSLLD 407
                  |||.|       |.||:.|            ...::|:|..|..||.:   ..:..|.|
Frog   371 ENNIRKALSFDNRGEEHKSTATAAT------------ENQLSGTGENGENGEVKLHEHKRTGLED 423

  Fly   408 FNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDDVDCTMTEKRILALAANHPFLTAL 472
            |||||||||||||||||||.||.||:||:||||||.|:||||||||||||||||||..||:||.|
Frog   424 FNFIKVLGKGSFGKVMLAELKGRDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARRHPYLTQL 488

  Fly   473 HSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAAEVTLALQFLHTHGVIYRDLKLDN 537
            :.||||.||||||||||||||||||||::|:|:..|:.|||||||.||.|||.||||||||||||
Frog   489 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDN 553

  Fly   538 ILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEILKEQEYGASVDWWALGVLMYEMMA 602
            ||||.||||||||||||||||:||:.||||||||||||||||:|.|||.||||||||||||||||
Frog   554 ILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 618

  Fly   603 GQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTKNPEQRLGCT---GDENEIRKHPF 664
            |||||||||||:||:||:|||||||||||:|||||||.|:||||.:||||.   |.|..|::|||
Frog   619 GQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPNKRLGCVAAQGLEEAIKQHPF 683

  Fly   665 FAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTPIGNEVVRCINQDEFAGFSFVN 729
            |.::||..||:|.:||||:|::|..||.||||.:||:|:||||.:...:|:.|||:||.|||:
Frog   684 FKEIDWVLLEQRKVKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY-- 746

  Fly   730 PKFGPE 735
              ||.|
Frog   747 --FGEE 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkc98E	NP_001287577.1	C2_PKC_epsilon	1..134	CDD:175981	57/132 (43%)
		C1_1	177..228	CDD:278556	40/51 (78%)
		C1_1	252..304	CDD:278556	34/51 (67%)
		STKc_nPKC_epsilon	412..729	CDD:270743	242/319 (76%)
prkce	XP_012818146.1	C2_PKC_epsilon	3..135	CDD:175981	57/133 (43%)
		C1_1	170..220	CDD:365894	38/49 (78%)
		C1_1	243..293	CDD:365894	32/49 (65%)
		STKc_nPKC_epsilon	428..748	CDD:270743	242/323 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	445	1.000	Domainoid score	I525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48343
Inparanoid	1	1.050	867	1.000	Inparanoid score	I415
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		oto102514
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090