DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slu7 and slu7

DIOPT Version :9

Sequence 1:	NP_651659.2	Gene:	Slu7 / 43427	FlyBaseID:	FBgn0039626	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_005169668.1	Gene:	slu7 / 492495	ZFINID:	ZDB-GENE-041114-62	Length:	619	Species:	Danio rerio

Alignment Length:	582	Identity:	302/582 - (51%)
Similarity:	383/582 - (65%)	Gaps:	59/582 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EEPKKKSREDWRKAKELEEARKAGTAPAAVDEEGRDINPHIPQYISNAPWYYG-SAGPTLKHQRP 87
            |||||.:||||||.|||||.||.|.|||.|||||:|||||||||||:.|||.. |..||||||||
Zfish    64 EEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRP 128

  Fly    88 QHEDEQGQLDKRAP------KGLNTARIITKFRKGACENCGAVTHKRKDCLERPRKVQAKYAESI 146
            |.|::    .|.||      :|:....:.||:||||||||||:|||:||||||||||.||::.:.
Zfish   129 QEENQ----SKFAPIGDWYKRGVQEKSVNTKYRKGACENCGALTHKKKDCLERPRKVGAKFSGTG 189

  Fly   147 VVHDEHLVNEAAVNYDEKRDRWSSYDPANHREIIEEYEKVEEAKRQLKAEKLKNDPDA------- 204
            :..|||...:.:::||.|||||:.|||..|..|:|||.||:.|||.|||:||:.:..:
Zfish   190 IAPDEHQQVQLSMDYDGKRDRWNGYDPDEHMRIVEEYSKVDLAKRTLKAQKLQEELASGKLMDQA 254

  Fly   205 ----------EISDEEGNEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYD 259
                      :.|.|:.:||||||:.||||...|||:||||||||||||.|||||||||||||||
Zfish   255 NSRKHEEAVQDHSSEDEDEDKYVDDFDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYD 319

  Fly   260 PKTRSMRDNP--NPAVPEEEAEFAGENFVRFSGDTTAQATAQLFAWEAHGKGVDVHLLAEPTKLE 322
            ||||:||:||  |.....||..:||:||||:||||.:.|..|||||||:.||.:|||.|:|||||
Zfish   320 PKTRAMRENPYSNTGKNPEEVGYAGDNFVRYSGDTISMAQTQLFAWEAYEKGSEVHLQADPTKLE 384

  Fly   323 LLQKEYEQKKEQFKSSTKTHIVEKYGGEEHLQVPPKSLLLAQTEEYIEYSRSGKVIKGVEKPKAR 387
            ||.:.|:.||:.||...|..|:|||||.|||..||:.|||||||||:||||.|.|:||.||..|:
Zfish   385 LLHQSYKVKKDDFKEKQKETILEKYGGSEHLDAPPRELLLAQTEEYVEYSRHGAVLKGQEKAVAQ 449

  Fly   388 SIYEEDVYINNHTTVWGSFWNAGRWGYKCCKSFIKNSYCVGMQEPEGYSEHHSTSSTAAATTEPA 452
            |.|||||..||||.:|||:|..|.||||||.|.:|.|||.|    |...:..|.|.|
Zfish   450 SKYEEDVLNNNHTCIWGSYWKDGYWGYKCCHSMVKQSYCTG----EAGKKVVSNSCT-------- 502

  Fly   453 AQSQFKVPEVPPERPTSEVDSASSSEPSS---SEEEEVKPEKKKTKKKSKKREKKKKAKEQRKQK 514
                      |.|....|  :.:|.||.:   ..:|::|.:|||.|.|..:.......:::.|:|
Zfish   503 ----------PFEEDVEE--AQTSEEPKTLLQMHQEKLKDKKKKKKSKKHRDSDSSDEEDEAKKK 555

  Fly   515 GKNKETKDKDKTKEKDIPE--ELDDRKRAYNSMYDVKAPTEDEIEEWKKKRPRAEDPMLQFM 574
            .|.|:....::.:.|.:.|  ::|:|||.|||:.:|:.|||:|:|.::.||.|.:|||..|:
Zfish   556 EKLKKALSAEEQRLKQVAELMQVDERKRPYNSLMEVREPTEEEMEAFRMKRCRPDDPMASFL 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slu7	NP_651659.2	Slu7	160..405	CDD:371683	157/263 (60%)
slu7	XP_005169668.1	Slu7	202..467	CDD:288545	157/264 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573393
Domainoid	1	1.000	315	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG2560
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4690
Inparanoid	1	1.050	574	1.000	Inparanoid score	I1011
OMA	1	1.010	-	-		QHG54674
OrthoDB	1	1.010	-	-		D192250at33208
OrthoFinder	1	1.000	-	-		FOG0003809
OrthoInspector	1	1.000	-	-		oto39960
orthoMCL	1	0.900	-	-		OOG6_101940
Panther	1	1.100	-	-	LDO	PTHR12942
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1349
SonicParanoid	1	1.000	-	-		X2654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800