DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slu7 and Slu7

DIOPT Version :9

Sequence 1:	NP_651659.2	Gene:	Slu7 / 43427	FlyBaseID:	FBgn0039626	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001094020.1	Gene:	Slu7 / 303057	RGDID:	631432	Length:	586	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	307/603 - (50%)
Similarity:	390/603 - (64%)	Gaps:	63/603 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PVSQIILSKHDQDAEEEPKKKSREDWRKAKELEEARKAGTAPAAVDEEGRDINPHIPQYISNAPW 73
            |||...::...:...|||||.:||||||.|||||.||.|.|||.|||||:|||||||||||:.||
  Rat     8 PVSATPMTGSKEMNLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPW 72

  Fly    74 YYG-SAGPTLKHQRPQHEDEQ-----GQLDKRAPKGLNTARIITKFRKGACENCGAVTHKRKDCL 132
            |.. |..|||||||||.|.::     |:..||   |:....|.||:||||||||||:|||||||.
  Rat    73 YIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKR---GVKENSITTKYRKGACENCGAMTHKRKDCF 134

  Fly   133 ERPRKVQAKYAESIVVHDEHLVNEAAVNYDEKRDRWSSYDPANHREIIEEYEKVEEAKRQLKAEK 197
            ||||:|.||:..:.:..|||:..:...:||.|||||:.|:|..|.:|:|||.||:.|||.|||:|
  Rat   135 ERPRRVGAKFTGTNIAPDEHIQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQK 199

  Fly   198 LK------------NDPDAEISDEEGN-------------EDKYVDEVDMPGTKVDSKQRITVRN 237
            |:            |.|..:..:||.|             ||||.|::||||...|||:||||||
  Rat   200 LQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRN 264

  Fly   238 LRIREDTAKYLRNLDPNSAYYDPKTRSMRDNP--NPAVPEEEAEFAGENFVRFSGDTTAQATAQL 300
            ||||||.|||||||||||||||||||:||:||  |.....:|..:||:||||::|||.:.|..||
  Rat   265 LRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQL 329

  Fly   301 FAWEAHGKGVDVHLLAEPTKLELLQKEYEQKKEQFKSSTKTHIVEKYGGEEHLQVPPKSLLLAQT 365
            |||||:.||.:|||.|:|||||||.|.::.|||.||...|..|:|||||:|||..||..||||||
  Rat   330 FAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQT 394

  Fly   366 EEYIEYSRSGKVIKGVEKPKARSIYEEDVYINNHTTVWGSFWNAGRWGYKCCKSFIKNSYCVGMQ 430
            |:|:||||.|.||||.|:..|.|.|||||.|||||.:|||:|..||||||||.||.|.|||.|..
  Rat   395 EDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEA 459

  Fly   431 EPEGYSEHHSTSSTAAATTEPAAQSQFKVPEVPPERPTSEVDSASSSEPSSSEEEEVKPEKKKTK 495
            ..|..:......:.|..             |.|.::|.:.::         ..:|::|.||||.|
  Rat   460 GKESVNSEECIINDATG-------------EEPVKKPQTLME---------LHQEKLKEEKKKKK 502

  Fly   496 KKSKKREKKKKA--KEQRKQKGKNKETKDKDKTKEKDIPE--ELDDRKRAYNSMYDVKAPTEDEI 556
            ||.|.|:....:  .|:|||: |.|:..:.::.:...:.|  ::|:|||.|||:|:.:.|||:|:
  Rat   503 KKKKHRKSSSDSDDDEERKQE-KLKKALNAEEARLLHVKEIMQVDERKRPYNSIYETREPTEEEM 566

  Fly   557 EEWKKKRPRAEDPMLQFM 574
            |.::.||.|.:|||..|:
  Rat   567 EAYRMKRQRPDDPMASFL 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slu7	NP_651659.2	Slu7	160..405	CDD:371683	157/271 (58%)
Slu7	NP_001094020.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		58/99 (59%)
		Bipartite nuclear localization signal. /evidence=ECO:0000250	129..169		19/39 (49%)
		Slu7	161..434	CDD:288545	175/299 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..254		36/60 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..586		30/82 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334370
Domainoid	1	1.000	312	1.000	Domainoid score	I1267
eggNOG	1	0.900	-	-		E1_KOG2560
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4690
Inparanoid	1	1.050	578	1.000	Inparanoid score	I995
OMA	1	1.010	-	-		QHG54674
OrthoDB	1	1.010	-	-		D192250at33208
OrthoFinder	1	1.000	-	-		FOG0003809
OrthoInspector	1	1.000	-	-		oto98729
orthoMCL	1	0.900	-	-		OOG6_101940
Panther	1	1.100	-	-	LDO	PTHR12942
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2654
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770