Protein Alignment Cpsf100 and YSH1

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_013379.1
• Gene: YSH1 / 850983
• SGDID: S000004267
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 812
• Identity: 188/812 - (23%)
• Similarity: 328/812 - (40%)
• Gaps: 197/812 - (24%)

  Fly     2 TSIIKLHTISGAMDESPPCYILQIDDVRILLDCG-------------WDEKFDANFIKELKRQVH 53
            |:..|..::.|:.:....|:|||.....::||.|             :|| ||          :.
Yeast     6 TTTFKFFSLGGSNEVGRSCHILQYKGKTVMLDAGIHPAYQGLASLPFYDE-FD----------LS 59

  Fly    54 TLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYATIPVFKMGQMFMYD------LYMSHFNMG--D 110
            .:|.:|:||....|..:|||::.:......::.|.|...:.:..:.|      :..|..:||  |
Yeast    60 KVDILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIYRWLLRDFVRVTSIGSSSSSMGTKD 124

  Fly   111 FDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATD 175
            ..|||.:|:..:|:||..:.|:.||.:.    ||..|..:|||::|..:::|...|.. :::..|
Yeast   125 EGLFSDEDLVDSFDKIETVDYHSTVDVN----GIKFTAFHAGHVLGAAMFQIEIAGLR-VLFTGD 184

  Fly   176 FNHKKERHLSGCELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTA 240
            ::.:.:|||:..|:..|....|::...:.....:.|.. |:.||...|..||...|.||:.|...
Yeast   185 YSREVDRHLNSAEVPPLSSNVLIVESTFGTATHEPRLN-RERKLTQLIHSTVMRGGRVLLPVFAL 248

  Fly   241 GRVLELAHMLDQLWKN--KESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPF 303
            ||..|:..:||:.|..  .|.|.....:...:|::...:...::.:..|:|.:.|.|..::.|||
Yeast   249 GRAQEIMLILDEYWSQHADELGGGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPF 313

  Fly   304 QFKHIQLCHSLADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAME 368
            .||:|....:|.|....  ||.|:|||...|:||.:|||..:|.....|.:::|..:..||:|..
Yeast   314 IFKNISYLRNLEDFQDF--GPSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKF 376

  Fly   369 LVENCAPGKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKP---DVEEESSS---ESEDDIE 427
            ::        :|.|....::                 ||.|..|   .|||.|.:   :.::::|
Yeast   377 IM--------LEPDTIPSIN-----------------NPEITIPRRCQVEEISFAAHVDFQENLE 416

  Fly   428 -MSVITGKHDIVV----RPEGRHHSGFFK-------SNKRHHVMFPYHEEKVKCDEYG------- 473
             :..|:..:.|:|    .|.||..|....       ::...||..|.:..:|..:..|
Yeast   417 FIEKISAPNIILVHGEANPMGRLKSALLSNFASLKGTDNEVHVFNPRNCVEVDLEFQGVKVAKAV 481

  Fly   474 -----EIINLDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKPTK- 532
                 ||...::..|.:....:..|::|:|::|:         :.||..|:||      |:..|
Yeast   482 GNIVNEIYKEENVEIKEEIAAKIEPIKEENEDNL---------DSQAEKGLVD------EEEHKD 531

  Fly   533 ------LISQRKTIEVNAQVQRIDFEGRSDGESMLKILSQ--LRPRRVIVIHGTAEGTQVVARHC 589
                  |:|..|..|       :||...||.......||.  ||.|            |.|..:|
Yeast   532 IVVSGILVSDDKNFE-------LDFLSLSDLREHHPDLSTTILRER------------QSVRVNC 577

  Fly   590 EQNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDAEVAWVDGRLGMRVKAIEAP 654
                        |.|:|    ..||.|:              ..:|||...|.|:     ..:.|
Yeast   578 ------------KKELI----YWHILQM--------------FGEAEVLQDDDRV-----TNQEP 607

  Fly   655 MDVTVEQDASVQEGKTLTLETLADDEIPIHNSVLINELKLSDFKQTLMRNNINSEFSGGVLWCSN 719
            ......:|.....|| |.|:.:.|.::.|     :|.|.:.::.|.||.:.:           ::
Yeast   608 KVKEESKDNLTNTGK-LILQIMGDIKLTI-----VNTLAVVEWTQDLMNDTV-----------AD 655

  Fly   720 GTLA-LRRVDAG----KVAMEGCLSEEYYKIR 746
            ..:| |..||:.    |::...|...::..::
Yeast   656 SIIAILMNVDSAPASVKLSSHSCDDHDHNNVQ 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	53/217 (24%)
		Beta-Casp	243..369	CDD:214983	37/127 (29%)
		RMMBL	539..600	CDD:462191	13/62 (21%)
		CPSF100_C	617..753	CDD:463836	24/135 (18%)
YSH1	NP_013379.1	CPSF3-like_MBL-fold	9..210	CDD:293850	54/216 (25%)
		YSH1	14..432	CDD:440849	117/461 (25%)
		CPSF73-100_C	533..777	CDD:463330	46/226 (20%)