Protein Alignment Cpsf100 and CFT2

DIOPT Version :10

• Sequence 1: NP_651658.1
• Gene: Cpsf100 / 43426
• FlyBaseID: FBgn0027873
• Length: 756
• Species: Drosophila melanogaster
• Sequence 2: NP_013216.1
• Gene: CFT2 / 850806
• SGDID: S000004105
• Length: 859
• Species: Saccharomyces cerevisiae
• Alignment Length: 888
• Identity: 200/888 - (22%)
• Similarity: 375/888 - (42%)
• Gaps: 204/888 - (22%)

  Fly    22 ILQIDDVRILLDCGWDEKFDA--NFIKELKRQVHTLDAVLLSHPDAYHLGA--------LPYLVG 76
            :::.|:|.:|:|.||:....:  ..||..::.:..:|.::||.|....|||        ..:.:.
Yeast    19 VVRFDNVTLLIDPGWNPSKVSYEQCIKYWEKVIPEIDVIILSQPTIECLGAHSLLYYNFTSHFIS 83

  Fly    77 KLGLNCPIYATIPVFKMGQMFMYDLYMSHFNMGDFDLFSLD--DVDTAFEKITQLKYNQTVSLKD 139
            ::    .:|||:||..:|::...|.|.|...:|.:|...||  |::.:|:.|..|||:|.|.|:.
Yeast    84 RI----QVYATLPVINLGRVSTIDSYASAGVIGPYDTNKLDLEDIEISFDHIVPLKYSQLVDLRS 144

  Fly   140 KGYGISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFNHKKERHL--------SGCELDRLQRPS 196
            :..|:::...|||...||:|| .:....|.:|||..:||.::..|        :|..|..|.|||
Yeast   145 RYDGLTLLAYNAGVCPGGSIW-CISTYSEKLVYAKRWNHTRDNILNAASILDATGKPLSTLMRPS 208

  Fly   197 LLIT--DAYNAQYQQARRRARDEKLMTNILQT-VRNNGNVLIAVDTAGRVLELAHMLDQLW--KN 256
            .:||  |.:.:. |..::|:   |:..:.|:. :.::|:|:|.||.:|:.|:|...:.:|.  ..
Yeast   209 AIITTLDRFGSS-QPFKKRS---KIFKDTLKKGLSSDGSVIIPVDMSGKFLDLFTQVHELLFEST 269

  Fly   257 KESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNN--PFQF-KHIQLCHSLADVY 318
            |.:......:.:|:......:.:|||.:||:|..|.|.:|. |||  ||:. ..|::. :..::.
Yeast   270 KINAHTQVPVLILSYARGRTLTYAKSMLEWLSPSLLKTWEN-RNNTSPFEIGSRIKII-APNELS 332

  Fly   319 KLPAGPKVVLASTPDLESG-FTRDLFVQWASNANNSIILTTRT----SPGTLAMELVEN------ 372
            |.| |.|:...|    |.| ...::.::..::...::|||..:    |.....:|:||.
Yeast   333 KYP-GSKICFVS----EVGALINEVIIKVGNSEKTTLILTKPSFECASSLDKILEIVEQDERNWK 392

  Fly   373 --CAPGKQ------IELDVRRRVDLEGAE-------LEEYLRTQGEKLNPLIVK----------- 411
              ...||.      |.:|..:...|...|       |:|..|.:.:|:  |:||
Yeast   393 TFPEDGKSFLCDNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKI--LLVKRESKKLANGNA 455

  Fly   412 ------------------------PDV------EEESSSESEDDIEMSVITGKH----------- 435
                                    |.:      :|:...|.|:|..::::....
Yeast   456 IIDDTNGERAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNLLKDNSEKSAAKKNTEV 520

  Fly   436 --DIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEI----------------------- 475
              ||:::|          |....|.|||::..|:|.|:||.:
Yeast   521 PVDIIIQP----------SAASKHKMFPFNPAKIKKDDYGTVVDFTMFLPDDSDNVNQNSRKRPL 575

  Fly   476 ---------INLDDYRIADATGYEFV-PMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLLEKP 530
                     :|.:|.:..:..||... |:.:::|....:.....|..:..|   .||...|  |.
Yeast   576 KDGAKTTSPVNEEDNKNEEEDGYNMSDPISKRSKHRASRYSGFSGTGEAEN---FDNLDYL--KI 635

  Fly   531 TKLISQRKTIEVNAQ----VQRIDFEGRSDGESMLKILSQLRPRRVIV-IHGTAEGTQVVARHCE 590
            .|.:|:|....||.|    |..::.:...|..|...|...|:.|:::: .....:..::.|:..:
Yeast   636 DKTLSKRTISTVNVQLKCSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAKLIK 700

  Fly   591 QNVGARVFTPQKGEIIDVTSEIHIYQVRLTEGLVSQLQFQKGKDA-EVAWVDGRLGMRVKAIEAP 654
            :|:  .|......:|::.::.|....:.:...|.:.|::|:..|: .||.|.|||   ||  |:.
Yeast   701 KNI--EVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISDSYTVATVVGRL---VK--ESL 758

  Fly   655 MDVTVEQDASVQEGKTLTLETLADDEIPIHNS--------VLINELKLSDFKQTLMRNNINSEFS 711
            ..|...|..:.:....|.         |:|.|        :.|.:::|:..|:.|...|..:||.
Yeast   759 PQVNNHQKTASRSKLVLK---------PLHGSSRSHKTGALSIGDVRLAQLKKLLTEKNYIAEFK 814

  Fly   712 GGVLWCSNGTLALRRVDAGKVAMEGCLSEEYYKIRELLYEQYA 754
            |......|..:|:|:::..:..::|..||.:..:::|:.:..|
Yeast   815 GEGTLVINEKVAVRKINDAETIIDGTPSELFDTVKKLVTDMLA 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	61/203 (30%)
		Beta-Casp	243..369	CDD:214983	31/135 (23%)
		RMMBL	539..600	CDD:462191	12/65 (18%)
		CPSF100_C	617..753	CDD:463836	34/144 (24%)
CFT2	NP_013216.1	Lactamase_B_6	19..211	CDD:406948	58/196 (30%)
		Beta-Casp	254..372	CDD:214983	30/124 (24%)
		CPSF100_C	732..856	CDD:463836	33/137 (24%)