DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cpsf100 and dclre1b

DIOPT Version :10

Sequence 1:NP_651658.1 Gene:Cpsf100 / 43426 FlyBaseID:FBgn0027873 Length:756 Species:Drosophila melanogaster
Sequence 2:NP_001070751.1 Gene:dclre1b / 768137 ZFINID:ZDB-GENE-061013-328 Length:571 Species:Danio rerio


Alignment Length:588 Identity:111/588 - (18%)
Similarity:194/588 - (32%) Gaps:189/588 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 IDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGALPYLVGKLGLNC-----PI 84
            :.|..|.:|| |          :|::.:| :....|||..:.|         ..||:.     ||
Zfish     6 LPDTPIAVDC-W----------QLRKCLH-VRLFFLSHMHSDH---------TCGLSSTWSHRPI 49

  Fly    85 YATIPVFKMGQMFMY--DLYMSHFNMGDFDLFSLDDVDTAFEKITQLKYNQTVSLKDKGYGISIT 147
            |.:....|:.::.:.  ..::....:|...:..|||:.         |...||:|          
Zfish    50 YCSPLTAKLLRLKLQIKQKWIRPLEIGQDHMLMLDDLG---------KERLTVNL---------- 95

  Fly   148 PLNAGHMIGGTIWKIV-KVGEEDIVYATDFNHKKERHLSGCELDRLQRPSLLITDAYNAQYQQAR 211
             ::|.|..|..::... ..|..  :|..||.:........|..:.:....|.:.   |......|
Zfish    96 -IDANHCPGAVMFLFQGYFGTR--LYTGDFRYTPSMLRVPCLQNHINIDVLYLD---NTNCDPTR 154

  Fly   212 RRARDEKLMTNILQTVRNN------------GNVLIAVDTAG----------------RVLELAH 248
            .....::....|.|.:|::            |...:.||.|.                |||:|..
Zfish   155 ALPSRQQATQLIKQIIRDHPGYAVVIGLYSLGKESLLVDLAMEFKTWVEVDRERLETLRVLQLPD 219

  Fly   249 MLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFEGARNNPFQFKHIQLCHS 313
            :.     ..:||  |..:.::|....|    |.:.:.|...:.|.|.....      :.:..|| 
Zfish   220 VF-----TTDSG--AGRIRVVNQSMIN----ASNLMAWNKLQSTIAILPTS------RPMVSCH- 266

  Fly   314 LADVYKLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSPGTLAMELVENCAPGKQ 378
             .:||.:|....   :|..:||.      ||             :..||.:| :.:|.||.|...
Zfish   267 -PNVYVVPYSDH---SSYQELED------FV-------------SALSPISL-VPIVGNCLPYFS 307

  Fly   379 IELDVRR--RVDLEGAELEEYLRTQG---EKLNPLI---VKPDV--------EEESSSESEDDIE 427
            ..|..||  :..:....:::|:.|..   ...|.:|   .:|:|        |.:.|..:.||::
Zfish   308 SLLSPRRKPKAVVIPESVKQYMMTNSNIQSSANGMIQRTSRPEVRGVVFDSPETKLSQPNHDDMD 372

  Fly   428 MSVITGKHDIVVRPE-----------GRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDY 481
            .:.....||...|..           ..:|....:.|||..:|....|:.|              
Zfish   373 SNDTEIDHDTTDRNSDSDCILLDMGTNSYHRDNDQRNKRLKLMRIESEDVV-------------- 423

  Fly   482 RIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIVDNDVQLL-----EKPTKLISQRKTIE 541
                 |....:.|::....:.:|   |||:.          |..|:     |.||| .|:.|:.|
Zfish   424 -----TVTSSLTMDDNESVSTRK---GIGSP----------DPSLIYECDHESPTK-SSKEKSPE 469

  Fly   542 VNA 544
            :.:
Zfish   470 MGS 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cpsf100NP_651658.1 CPSF2-like_MBL-fold 7..204 CDD:293851 34/186 (18%)
Beta-Casp 243..369 CDD:214983 25/125 (20%)
RMMBL 539..600 CDD:462191 1/6 (17%)
CPSF100_C 617..753 CDD:463836
dclre1bNP_001070751.1 SNM1A-1C-like_MBL-fold 4..152 CDD:293831 35/191 (18%)
DRMBL 217..302 CDD:429512 24/126 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..386 8/39 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..487 14/56 (25%)
TBM 501..532
Blue background indicates that the domain is not in the aligned region.

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