DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpsf100 and DCLRE1C

DIOPT Version :9

Sequence 1:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster
Sequence 2:	NP_001029027.1	Gene:	DCLRE1C / 64421	HGNCID:	17642	Length:	692	Species:	Homo sapiens

Alignment Length:	834	Identity:	160/834 - (19%)
Similarity:	249/834 - (29%)	Gaps:	338/834 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIKELKRQVHTLDAVLLSHPDAYHLGAL 71
            :.:..|.|.|.|...|               ::||        |:.....|..|||....|:..|
Human     1 MSSFEGQMAEYPTISI---------------DRFD--------RENLRARAYFLSHCHKDHMKGL 42

  Fly    72 --PYLVGKLGLNCPIYA-TIPVFKMGQMFMYDLYMS--HFNMGDFDLFSLDDVDTAFEKITQLKY 131
              |.|..:|..:..:|. ..||.|       :|.::  .:......:.|::     .|..||
Human    43 RAPTLKRRLECSLKVYLYCSPVTK-------ELLLTSPKYRFWKKRIISIE-----IETPTQ--- 92

  Fly   132 NQTVSLKDKGYG----ISITPLNAGHMIGGTIWKIVKVGEEDIVYATDFN------HKKERHLSG 186
               :||.|:..|    |.:|.|.|||..|..:: :.:.....::|..||.      .:.|...||
Human    93 ---ISLVDEASGEKEEIVVTLLPAGHCPGSVMF-LFQGNNGTVLYTGDFRLAQGEAARMELLHSG 153

  Fly   187 CELDRLQRPSLLITDAYNAQYQQARRRARDEKLMTNILQTVRNNGNVLIAVDTAGRVLELAHMLD 251
            ..:..:|...|..|......||...|    |:.::.:|:.||:
Human   154 GRVKDIQSVYLDTTFCDPRFYQIPSR----EECLSGVLELVRS---------------------- 192

  Fly   252 QLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMSDKLTKAFE----------GA-------- 298
              |              :....|:|:        |::.|....:|          |.
Human   193 --W--------------ITRSPYHVV--------WLNCKAAYGYEYLFTNLSEELGVQVHVNKLD 233

  Fly   299 --RNNPFQFKH--------IQLC-HSLADVY----KLPAG-------PKVVLASTPDLESGFTRD 341
              ||.|....|        |..| |..|:.|    |||.|       |..:::..|.
Human   234 MFRNMPEILHHLTTDRNTQIHACRHPKAEEYFQWSKLPCGITSRNRIPLHIISIKPS-------- 290

  Fly   342 LFVQW---ASNANNSIILTTRTS--------------------------------PGTLAMELVE 371
              ..|   .|...|.|:.|..:|                                .||...::||
Human   291 --TMWFGERSRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVE 353

  Fly   372 NCAPGKQIELDVRRRVDLEGAELEEYLRTQGEKLNPLIVKPDVEEESSSESEDDIEMSVITGKHD 436
            ...|           :.......|...:..|:......|..|.|||.....:|.:.:.:
Human   354 ILKP-----------LCRSSQSTEPKYKPLGKLKRARTVHRDSEEEDDYLFDDPLPIPL------ 401

  Fly   437 IVVRPEGRHHSGFFKSNKRHHVMFP--YHEE----------------------KVKCDEYGEIIN 477
                              ||.|.:|  :|.|                      :.:|.:.....|
Human   402 ------------------RHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQSSRFTN 448

  Fly   478 LDDYRIADATGYEFVPMEEQNKENVKKEEPGIGAEQQANGGIV------DNDV---QLLEKPTKL 533
                         ||..||.|.|:  :||.||.|..|.:.|.|      |.||   ::..|....
Human   449 -------------FVDCEESNSES--EEEVGIPASLQGDLGSVLHLQKADGDVPQWEVFFKRNDE 498

  Fly   534 ISQR-------KTIEVNAQVQRIDFEGRSDGESMLKILSQLRPRRVIVIHGTAEGTQ-------- 583
            |:..       .|:...:|..::..:  ||||| ..|.||...:..   |.|.:|:|
Human   499 ITDESLENFPSSTVAGGSQSPKLFSD--SDGES-THISSQNSSQST---HITEQGSQGWDSQSDT 557

  Fly   584 VVARHCEQNVGARVFTPQKGEIIDVTS-EIHIYQVRLTEGLVSQLQFQ------------KGKDA 635
            |:....|:|.|            |:|| :...|:..:.|.:.:.|..|            |.:|.
Human   558 VLLSSQERNSG------------DITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDK 610

  Fly   636 EVAWVDGRLGMRVKAIEAPMDVTVEQDASVQEGKT-LTLETLADD------EIP 682
            :|..|.          ......|:..:..:.|.|: |.|.|.||.      |:|
Human   611 DVTIVP----------STGEPTTLSSETHIPEEKSLLNLSTNADSQSSSDFEVP 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	46/211 (22%)
		YSH1	19..400	CDD:224157	83/470 (18%)
		Beta-Casp	243..369	CDD:214983	30/200 (15%)
		RMMBL	538..577	CDD:284853	10/38 (26%)
		CPSF100_C	617..753	CDD:290038	17/85 (20%)
DCLRE1C	NP_001029027.1	artemis-SNM1C-like_MBL-fold	1..171	CDD:293855	46/211 (22%)
		DRMBL	239..343	CDD:284854	19/113 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..555		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..664		5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900